Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2.
COVID-19
sex difference
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
pubmed:
12
11
2020
medline:
12
11
2020
entrez:
11
11
2020
Statut:
epublish
Résumé
Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clinical data. We first compiled 220,000 human gene expression profiles from three databases and completed the meta-information through machine learning and manual annotation. Large scale analysis of these profiles indicated that male samples show higher expression levels of
Identifiants
pubmed: 33173861
doi: 10.21203/rs.3.rs-100914/v1
pmc: PMC7654875
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : K01 ES028047
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134307
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.
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