Natural language markers of social phenotype in girls with autism.
Autism spectrum condition
language
pronouns
sex differences
social phenotype
Journal
Journal of child psychology and psychiatry, and allied disciplines
ISSN: 1469-7610
Titre abrégé: J Child Psychol Psychiatry
Pays: England
ID NLM: 0375361
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
25
09
2020
received:
13
09
2019
accepted:
29
09
2020
pubmed:
12
11
2020
medline:
21
10
2021
entrez:
11
11
2020
Statut:
ppublish
Résumé
Girls with autism spectrum condition (ASC) are chronically underdiagnosed compared to boys, which may be due to poorly understood sex differences in a variety of domains, including social interest and motivation. In this study, we use natural language processing to identify objective markers of social phenotype that are easily obtained from a brief conversation with a nonexpert. 87 school-aged children and adolescents with ASC (17 girls, 33 boys) or typical development (TD; 15 girls, 22 boys) were matched on age (mean = 11.35 years), IQ estimates (mean = 107), and - for ASC participants - level of social impairment. Participants engaged in an informal 5-min 'get to know you' conversation with a nonexpert conversation partner. To measure attention to social groups, we analyzed first-person plural pronoun variants (e.g., 'we' and 'us') and third-person plural pronoun variants (e.g., 'they' and 'them'). Consistent with prior research suggesting greater social motivation in autistic girls, autistic girls talked more about social groups than did ASC boys. Compared to TD girls, autistic girls demonstrated atypically heightened discussion of groups they were not a part of ('they', 'them'), indicating potential awareness of social exclusion. Pronoun use predicted individual differences in the social phenotypes of autistic girls. Relatively heightened but atypical social group focus is evident in autistic girls during spontaneous conversation, which contrasts with patterns observed in autistic boys and TD girls. Quantifying subtle linguistic differences in verbally fluent autistic girls is an important step toward improved identification and support for this understudied sector of the autism spectrum.
Sections du résumé
BACKGROUND
Girls with autism spectrum condition (ASC) are chronically underdiagnosed compared to boys, which may be due to poorly understood sex differences in a variety of domains, including social interest and motivation. In this study, we use natural language processing to identify objective markers of social phenotype that are easily obtained from a brief conversation with a nonexpert.
METHODS
87 school-aged children and adolescents with ASC (17 girls, 33 boys) or typical development (TD; 15 girls, 22 boys) were matched on age (mean = 11.35 years), IQ estimates (mean = 107), and - for ASC participants - level of social impairment. Participants engaged in an informal 5-min 'get to know you' conversation with a nonexpert conversation partner. To measure attention to social groups, we analyzed first-person plural pronoun variants (e.g., 'we' and 'us') and third-person plural pronoun variants (e.g., 'they' and 'them').
RESULTS
Consistent with prior research suggesting greater social motivation in autistic girls, autistic girls talked more about social groups than did ASC boys. Compared to TD girls, autistic girls demonstrated atypically heightened discussion of groups they were not a part of ('they', 'them'), indicating potential awareness of social exclusion. Pronoun use predicted individual differences in the social phenotypes of autistic girls.
CONCLUSIONS
Relatively heightened but atypical social group focus is evident in autistic girls during spontaneous conversation, which contrasts with patterns observed in autistic boys and TD girls. Quantifying subtle linguistic differences in verbally fluent autistic girls is an important step toward improved identification and support for this understudied sector of the autism spectrum.
Identifiants
pubmed: 33174202
doi: 10.1111/jcpp.13348
pmc: PMC9113519
mid: NIHMS1640342
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
949-960Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC018289
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD086984
Pays : United States
Organisme : NICHD NIH HHS
ID : 5U54HD086984
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01DC018289
Pays : United States
Informations de copyright
© 2020 Association for Child and Adolescent Mental Health.
Références
Autism. 2016 May;20(4):442-62
pubmed: 26134030
Mol Autism. 2017 Sep 30;8:48
pubmed: 29021889
Br J Disord Commun. 1989 Aug;24(2):169-79
pubmed: 2605110
Trends Cogn Sci. 2012 Apr;16(4):231-9
pubmed: 22425667
J Exp Psychol Gen. 2017 Mar;146(3):337-346
pubmed: 28114772
J Am Acad Child Adolesc Psychiatry. 2017 Jun;56(6):466-474
pubmed: 28545751
J Child Psychol Psychiatry. 2010 Nov;51(11):1227-34
pubmed: 20673234
Autism Res. 2016 Aug;9(8):854-65
pubmed: 26800246
Cognition. 2009 Feb;110(2):131-46
pubmed: 19111285
JAMA Psychiatry. 2018 Aug 1;75(8):797-808
pubmed: 29898209
J Autism Dev Disord. 2014 Sep;44(9):2087-95
pubmed: 24777286
Br J Disord Commun. 1980 May;15(1):39-43
pubmed: 7387869
J Child Psychol Psychiatry. 2014 Nov;55(11):1218-25
pubmed: 25039696
Autism Res. 2013 Dec;6(6):468-78
pubmed: 24124067
Arch Gen Psychiatry. 2012 Mar;69(3):306-13
pubmed: 22065253
Annu Rev Psychol. 2003;54:547-77
pubmed: 12185209
Mol Autism. 2016 Jan 19;7:7
pubmed: 26788284
J Autism Dev Disord. 1986 Sep;16(3):335-49
pubmed: 3558291
Health Psychol. 2016 Oct;35(10):1069-80
pubmed: 27441867
J Autism Dev Disord. 1994 Apr;24(2):155-76
pubmed: 8040159
Mol Autism. 2020 Jun 16;11(1):49
pubmed: 32546266
Autism. 2017 Aug;21(6):678-689
pubmed: 27899709
Autism. 2019 Jul;23(5):1119-1132
pubmed: 30280923
Autism Res. 2017 Apr;10(4):680-689
pubmed: 27809408
Mol Autism. 2016 Jan 21;7:10
pubmed: 26798446
J Autism Dev Disord. 2016 Mar;46(3):840-52
pubmed: 26438638
Br J Psychiatry. 2012 Apr;200(4):342-3
pubmed: 22403087
J Child Psychol Psychiatry. 2000 Oct;41(7):831-46
pubmed: 11079426
Front Psychol. 2015 Oct 09;6:1564
pubmed: 26500601
J Intellect Disabil Res. 2016 May;60(5):464-77
pubmed: 27120989
Res Autism Spectr Disord. 2016 Jul;27:11-20
pubmed: 27103941
J Autism Dev Disord. 2010 Jun;40(6):653-64
pubmed: 20013041
Mol Autism. 2019 Mar 27;10:14
pubmed: 30962869
J Speech Lang Hear Res. 2019 Jun 19;62(6):1787-1797
pubmed: 31112664
J Autism Dev Disord. 2016 Apr;46(4):1297-306
pubmed: 26695137
Mol Autism. 2019 Jun 28;10:28
pubmed: 31297179
Brain Lang. 2000 May;72(3):193-218
pubmed: 10764517
J Autism Dev Disord. 2019 Oct;49(10):4294-4305
pubmed: 31338717
J Autism Dev Disord. 2021 Apr;51(4):1353-1364
pubmed: 32691191
J Autism Dev Disord. 2016 Mar;46(3):1061-70
pubmed: 26586555
J Autism Dev Disord. 2020 May;50(5):1639-1656
pubmed: 30830491
Front Psychiatry. 2018 Dec 05;9:645
pubmed: 30568607
J Am Acad Child Adolesc Psychiatry. 2012 Aug;51(8):788-97
pubmed: 22840550
Psychol Sci. 2005 Dec;16(12):932-6
pubmed: 16313655
Autism Res. 2020 May;13(5):763-776
pubmed: 31799774
MMWR Surveill Summ. 2020 Mar 27;69(4):1-12
pubmed: 32214087
J Autism Dev Disord. 2018 May;48(5):1698-1711
pubmed: 29204929
Eur J Disord Commun. 1996;31(3):245-58
pubmed: 8944847
Am Psychol. 2015 Apr;70(3):255-64
pubmed: 25642702
MMWR Surveill Summ. 2018 Apr 27;67(6):1-23
pubmed: 29701730
J Autism Dev Disord. 2016 Oct;46(10):3281-94
pubmed: 27457364
Autism. 2008 Mar;12(2):173-90
pubmed: 18308766
J Autism Dev Disord. 2014 Oct;44(10):2400-12
pubmed: 23143131
Proc Conf. 2018 Jun;2018:147-157
pubmed: 33073267
Clin Linguist Phon. 2019;33(5):420-436
pubmed: 30346853
Psychol Methods. 2018 Jun;23(2):208-225
pubmed: 28277690
J Pers. 1988 Jun;56(2):393-404
pubmed: 3404383