Age-related electrophysiological changes in mouse taste receptor cells.
action potentials
in situ whole-cell recording
voltage-gated currents
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
24
09
2020
accepted:
09
11
2020
pubmed:
12
11
2020
medline:
25
2
2022
entrez:
11
11
2020
Statut:
ppublish
Résumé
What is the central question of this study? Loss of taste or inability to distinguish between different tastes progresses with age. The purpose was to evaluate the age-dependent changes in taste by studying the electrophysiological properties of taste receptor cells. What is the main finding and its importance? Ageing decreased the voltage-gated Na The loss of taste due to normal ageing in mammals is assumed to be caused by the ageing of taste receptor cells. We examined the electrophysiological properties of taste receptor cells in the fungiform taste buds of ∼20-month-old mice in situ and subsequently identified their cell types with immunological markers: the inositol 1,4,5-trisphosphate (IP
Substances chimiques
Inositol 1,4,5-Trisphosphate Receptors
0
Synaptosomal-Associated Protein 25
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
519-531Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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