Engineering the Interaction Dynamics between Nano-Topographical Immunocyte-Templated Micromotors across Scales from Ions to Cells.

cell templates macrophages micromotors nano-topographic surfaces propulsion

Journal

Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338

Informations de publication

Date de publication:
12 2020
Historique:
received: 23 08 2020
revised: 10 10 2020
pubmed: 12 11 2020
medline: 24 6 2021
entrez: 11 11 2020
Statut: ppublish

Résumé

Manufacturing mobile artificial micromotors with structural design factors, such as morphology nanoroughness and surface chemistry, can improve the capture efficiency through enhancing contact interactions with their surrounding targets. Understanding the interplay of such parameters targeting high locomotion performance and high capture efficiency at the same time is of paramount importance, yet, has so far been overlooked. Here, an immunocyte-templated nano-topographical micromotor is engineered and their interactions with various targets across multiple scales, from ions to cells are investigated. The macrophage templated nanorough micromotor demonstrates significantly increased surface interactions and significantly improved and highly efficient removal of targets from complex aqueous solutions, including in plasma and diluted blood, when compared to smooth synthetic material templated micromotors with the same size and surface chemistry. These results suggest that the surface nanoroughness of the micromotors for the locomotion performance and interactions with the multiscale targets should be considered simultaneously, for they are highly interconnected in design considerations impacting applications across scales.

Identifiants

pubmed: 33174334
doi: 10.1002/smll.202005185
doi:

Substances chimiques

Ions 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2005185

Subventions

Organisme : NCI NIH HHS
ID : U54 CA199075
Pays : United States

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Jie Wang (J)

Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.

Rajib Ahmed (R)

Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.

Yitian Zeng (Y)

Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305-4034, USA.

Kaiyu Fu (K)

Department of Electrical Engineering and Department of Radiology, Stanford University, Stanford, CA, 94305-4034, USA.

Fernando Soto (F)

Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.

Bob Sinclair (B)

Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305-4034, USA.

Hyongsok Tom Soh (HT)

Department of Electrical Engineering and Department of Radiology, Stanford University, Stanford, CA, 94305-4034, USA.

Utkan Demirci (U)

Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.

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