The effect of body mass index on hippocampal morphology and memory performance in late childhood and adolescence.
adolescence
body mass index
childhood
hippocampus
neuroanatomy
neuroimaging
pediatric obesity
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
15
04
2020
revised:
27
10
2020
accepted:
29
10
2020
pubmed:
12
11
2020
medline:
25
2
2022
entrez:
11
11
2020
Statut:
ppublish
Résumé
Childhood obesity is associated with negative physiological and cognitive health outcomes. The hippocampus is a diverse subcortical structure involved in learned feeding behaviors and energy regulation, and research has shown that the hippocampus is vulnerable to the effects of excess adiposity. Previous studies have demonstrated reduced hippocampal volume in overweight and obese children; however, it is unclear if certain subregions are selectively affected. The purpose of this study was to determine how excess body weight influences regional hippocampal surface morphology and memory performance in a large cross-sectional cohort of 588 children and adolescents between 8.33 and 19.92 years of age using body mass index expressed as a percentage of the 95th percentile cutoff (%BMIp95). We demonstrate %BMIp95 is associated with reduced radial thickness in the superior anterior region of the left hippocampus, and this relationship is predominantly driven by children younger than 14 years. We also found %BMIp95 was associated with worse performance on a spatial episodic memory task and this relationship was partially mediated by the radial thickness of the significant shape cluster. These results demonstrate the differential influence of excess body weight on regional hippocampal structure and hippocampal-dependent behavior in children and adolescents.
Identifiants
pubmed: 33174346
doi: 10.1002/hipo.23280
pmc: PMC9006989
mid: NIHMS1792195
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-200Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD065832
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020406
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094343
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2MH089924
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116858
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089983
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41EB015922
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH094343
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089924
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R00HD065832
Organisme : NIMH NIH HHS
ID : RC2MH089983
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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