Brain metabolic correlates of apathy in amyotrophic lateral sclerosis: An 18F-FDG-positron emission tomography stud.

Amyotrophic Lateral Sclerosis / diagnostic imaging Apathy Brain / diagnostic imaging Fluorodeoxyglucose F18 Humans Positron-Emission Tomography
18F-FDG-PET amyotrophic lateral sclerosis apathy

Journal

European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311

Informations de publication

Date de publication:
03 2021
Historique:
received: 31 08 2020
revised: 23 10 2020
accepted: 05 11 2020
pubmed: 12 11 2020
medline: 13 8 2021
entrez: 11 11 2020
Statut: ppublish

Résumé

The aim of this study was to evaluate brain metabolic correlates of apathy in amyotrophic lateral sclerosis (ALS). A total of 165 ALS patients underwent In the whole sample, the "after" apathy subscore negatively correlated with metabolism in the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), ventrolateral prefrontal cortex (VLPFC), premotor cortex (PMC) and anterior cingulate cortex (ACC), and insula bilaterally. A positive correlation was found in the cerebellum and pons. The "before-after" gap negatively correlated with metabolism in bilateral DLPFC, DMPFC and PMC, and left VLPFC and ACC, and positively correlated with cerebellar and pontine clusters. Among patients with an "after" apathy subscore ≥65, we found no difference between those with "before" apathy subscores ≥65 and <65. Patients with a "before-after" gap ≥22, compared to patients with a gap <22, showed relative hypometabolism in bilateral DLPFC and DMPFC, and left ACC and PMC, and relative cerebellar and pontine hypermetabolism. No studies on brain

Sections du résumé

BACKGROUND AND PURPOSE
The aim of this study was to evaluate brain metabolic correlates of apathy in amyotrophic lateral sclerosis (ALS).
METHODS
A total of 165 ALS patients underwent
RESULTS
In the whole sample, the "after" apathy subscore negatively correlated with metabolism in the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), ventrolateral prefrontal cortex (VLPFC), premotor cortex (PMC) and anterior cingulate cortex (ACC), and insula bilaterally. A positive correlation was found in the cerebellum and pons. The "before-after" gap negatively correlated with metabolism in bilateral DLPFC, DMPFC and PMC, and left VLPFC and ACC, and positively correlated with cerebellar and pontine clusters. Among patients with an "after" apathy subscore ≥65, we found no difference between those with "before" apathy subscores ≥65 and <65. Patients with a "before-after" gap ≥22, compared to patients with a gap <22, showed relative hypometabolism in bilateral DLPFC and DMPFC, and left ACC and PMC, and relative cerebellar and pontine hypermetabolism.
CONCLUSION
No studies on brain

Identifiants

DOI: 10.1111/ene.14637 PMID: 33175462
pubmed: 33175462
doi: 10.1111/ene.14637
doi:

Substances chimiques

Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

745-753

Informations de copyright

© 2020 European Academy of Neurology.

Références

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Auteurs

Antonio Canosa (A)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
ORCID: 0000-0001-5876-4079

Veria Vacchiano (V)

Bellaria Hospital, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
ORCID: 0000-0002-3607-2394

Fabrizio D'Ovidio (F)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
ORCID: 0000-0001-6304-5415

Andrea Calvo (A)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Neuroscience Institute of Turin (NIT), Turin, Italy.

Cristina Moglia (C)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

Umberto Manera (U)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Rosario Vasta (R)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
ORCID: 0000-0002-0393-4736

Rocco Liguori (R)

Bellaria Hospital, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
ORCID: 0000-0002-1815-1013

Vincenzo Arena (V)

Positron Emission Tomography Centre AFFIDEA-IRMET S.p.A, Turin, Italy.

Maurizio Grassano (M)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Francesca Palumbo (F)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Laura Peotta (L)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Barbara Iazzolino (B)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.

Marco Pagani (M)

Institute of Cognitive Sciences and Technologies, C.N.R, Rome, Italy.
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.

Adriano Chiò (A)

ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy.
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Neuroscience Institute of Turin (NIT), Turin, Italy.
Institute of Cognitive Sciences and Technologies, C.N.R, Rome, Italy.
ORCID: 0000-0001-9579-5341

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Brain metabolic correlates of apathy in...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Apathie › Brain metabolic correlates of apathy in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Brain metabolic correlates of apathy in...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Brain metabolic correlates of apathy in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Brain metabolic correlates of apathy in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Brain metabolic correlates of apathy in...