The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception.
Analgesia
Knockout mice
Mu opioid receptor
Neuropathic pain
Sigma 1 receptor
Sigma 2 receptor
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
received:
16
07
2020
accepted:
22
09
2020
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
6
8
2021
Statut:
epublish
Résumé
The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to investigate its potential role as a regulator of opioid analgesia and of pain hypersensitivity in σ2R knockout mice. In contrast to σ1R deficient mice, σ2R knockout mice developed mechanical allodynia following establishment of chronic constriction injury-induced neuropathic pain, which was alleviated by the σ1R antagonist S1RA. The analgesic effects of morphine, [D-Ala, N-MePhe, Gly-ol]-encephalin (DAMGO) and β-endorphin increased in σ1R
Identifiants
pubmed: 33176836
doi: 10.1186/s13041-020-00676-4
pii: 10.1186/s13041-020-00676-4
pmc: PMC7659117
doi:
Substances chimiques
Analgesics
0
RNA, Messenger
0
Receptors, Opioid, mu
0
Receptors, sigma
0
sigma-2 receptor
0
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
150Références
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