Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma.

Asthma Cesarean Section Child Female Gastrointestinal Microbiome Humans Pregnancy Prospective Studies RNA, Ribosomal, 16S / genetics

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
11 11 2020
Historique:
received: 10 05 2019
revised: 18 12 2019
accepted: 15 06 2020
entrez: 12 11 2020
pubmed: 13 11 2020
medline: 24 6 2021
Statut: ppublish

Résumé

There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood

Identifiants

DOI: 10.1126/scitranslmed.aax9929 PMID: 33177184
pubmed: 33177184
pii: 12/569/eaax9929
doi: 10.1126/scitranslmed.aax9929
pii:
doi:

Substances chimiques

RNA, Ribosomal, 16S 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Jakob Stokholm (J)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
Department of Pediatrics, Slagelse Hospital, 4200 Slagelse, Denmark.
ORCID: 0000-0003-4989-9769

Jonathan Thorsen (J)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
ORCID: 0000-0003-0200-0461

Martin J Blaser (MJ)

Departments of Medicine and Microbiology and Human Microbiome Program, New York University Langone Medical Center, New York, NY 10016, USA.
Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA.

Morten A Rasmussen (MA)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
Section of Chemometrics and Analytical Technologies, Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.
ORCID: 0000-0001-7431-5206

Mathis Hjelmsø (M)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
ORCID: 0000-0001-9716-624X

Shiraz Shah (S)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
ORCID: 0000-0002-4665-577X

Emil D Christensen (ED)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
ORCID: 0000-0002-5401-1819

Bo L Chawes (BL)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.

Klaus Bønnelykke (K)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.

Susanne Brix (S)

Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0001-8951-6705

Martin S Mortensen (MS)

Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
ORCID: 0000-0001-5483-7533

Asker Brejnrod (A)

Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA 92093, USA.
ORCID: 0000-0002-1327-2051

Gisle Vestergaard (G)

Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
Section of Bioinformatics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0003-2541-4974

Urvish Trivedi (U)

Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
ORCID: 0000-0003-1541-6212

Søren J Sørensen (SJ)

Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark. bisgaard@copsac.com sjs@bio.ku.dk.
ORCID: 0000-0001-6227-9906

Hans Bisgaard (H)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark. bisgaard@copsac.com sjs@bio.ku.dk.
ORCID: 0000-0003-4131-7592

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Delivery mode and gut microbial changes...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie obstétrique › Accouchement (procédure) › Césarienne › Delivery mode and gut microbial changes...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Delivery mode and gut microbial changes...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Delivery mode and gut microbial changes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Delivery mode and gut microbial changes...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Delivery mode and gut microbial changes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Delivery mode and gut microbial changes...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Delivery mode and gut microbial changes...