A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque.
Animals
Binding Sites
Female
Humans
Macaca mulatta
Male
Mutation
Respiratory Syncytial Virus Infections
/ immunology
Respiratory Syncytial Virus Vaccines
/ administration & dosage
Respiratory Syncytial Virus, Human
/ drug effects
S-Adenosylmethionine
/ metabolism
Sigmodontinae
Vaccination
Viral Envelope Proteins
/ genetics
Viral Proteins
/ genetics
Virus Replication
RSV
animal models
cotton rat
live attenuated vaccine
respiratory syncytial virus
rhesus macaque
vaccines
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
13 01 2021
13 01 2021
Historique:
received:
03
08
2020
accepted:
06
11
2020
pubmed:
13
11
2020
medline:
16
3
2021
entrez:
12
11
2020
Statut:
epublish
Résumé
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in children of <5 years of age worldwide, infecting the majority of infants in their first year of life. Despite the widespread impact of this virus, no vaccine is currently available. For more than 50 years, live attenuated vaccines (LAVs) have been shown to protect against other childhood viral infections, offering the advantage of presenting all viral proteins to the immune system for stimulation of both B and T cell responses and memory. The RSV LAV candidate described here, rgRSV-L(G1857A)-G(L208A), contains two modifications: an attenuating mutation in the
Identifiants
pubmed: 33177201
pii: JVI.01568-20
doi: 10.1128/JVI.01568-20
pmc: PMC7925107
pii:
doi:
Substances chimiques
Respiratory Syncytial Virus Vaccines
0
Viral Envelope Proteins
0
Viral Proteins
0
attachment protein G
0
S-Adenosylmethionine
7LP2MPO46S
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI112524
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI093848
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI112542
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002735
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Microbiology.
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