Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series.
Adaptive Immunity
Adult
Aged
Antibodies, Viral
/ metabolism
Betacoronavirus
/ immunology
Biomarkers
/ metabolism
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
Coronavirus Infections
/ diagnosis
Cytokines
/ metabolism
Humans
Immunity, Innate
Kinetics
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnosis
SARS-CoV-2
Severity of Illness Index
Viral Load
Virus Shedding
COVID-19
SARS-CoV-2
antibody response
cytokines
immunity
viral load
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
24
11
2020
Statut:
epublish
Résumé
Viral shedding patterns and their correlations with immune responses are still poorly characterized in mild coronavirus (CoV) disease 2019 (COVID-19). We monitored shedding of viral RNA and infectious virus and characterized the immune response kinetics of the first five patients quarantined in Geneva, Switzerland. High viral loads and infectious virus shedding were observed from the respiratory tract despite mild symptoms, with isolation of infectious virus and prolonged positivity by reverse transcriptase PCR (RT-PCR) until days 7 and 19 after symptom onset, respectively. Robust innate responses characterized by increases in activated CD14
Identifiants
pubmed: 33177214
pii: 5/6/e00827-20
doi: 10.1128/mSphere.00827-20
pmc: PMC7657589
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Vetter et al.
Références
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Aliment Pharmacol Ther. 2011 Oct;34(8):960-71
pubmed: 21848603
BMJ. 2020 Apr 17;369:m1470
pubmed: 32303495
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
J Clin Virol. 2020 Jun;127:104370
pubmed: 32344321
BMJ. 2020 Apr 7;369:m1328
pubmed: 32265220
J Gen Virol. 2005 Aug;86(Pt 8):2269-2274
pubmed: 16033974
J Infect Dis. 2020 Jul 07;:
pubmed: 32692346
Nat Rev Immunol. 2020 Jun;20(6):339-341
pubmed: 32317716
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
Cell Discov. 2020 May 4;6:31
pubmed: 32377375
J Clin Microbiol. 2014 Sep;52(9):3351-61
pubmed: 25009045
Clin Infect Dis. 2020 Jul 28;71(15):825-832
pubmed: 32277759
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Immunology. 2010 Jun;130(2):202-16
pubmed: 20113369
PLoS One. 2011;6(10):e25858
pubmed: 21998709
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
PLoS One. 2011 Mar 01;6(3):e17484
pubmed: 21390263
Front Immunol. 2017 Mar 13;8:272
pubmed: 28348563
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
J Leukoc Biol. 2020 Oct 11;:
pubmed: 33040384
Clin Microbiol Infect. 2020 Oct;26(10):1386-1394
pubmed: 32603801
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
Sci Immunol. 2020 Jun 26;5(48):
pubmed: 32591408
Cell Host Microbe. 2014 Jul 9;16(1):115-27
pubmed: 24981333
J Med Virol. 2020 Apr 28;:
pubmed: 32343429
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
J Virol. 2019 Mar 5;93(6):
pubmed: 30626681
Vaccine. 2020 Jun 26;38(31):4783-4791
pubmed: 32507409
Emerg Infect Dis. 2020 Oct;26(10):2494-2497
pubmed: 32603290