Assessing Cognitive Change and Quality of Life 12 Months After Epilepsy Surgery-Development and Application of Reliable Change Indices and Standardized Regression-Based Change Norms for a Neuropsychological Test Battery in the German Language.

cognitive decline improvement in quality of life longitudinal follow-up after epilepsy surgery minimal clinically important difference reliable change index standardized regression-based change norms

Journal

Frontiers in psychology
ISSN: 1664-1078
Titre abrégé: Front Psychol
Pays: Switzerland
ID NLM: 101550902

Informations de publication

Date de publication:
2020
Historique:
received: 13 07 2020
accepted: 14 09 2020
entrez: 12 11 2020
pubmed: 13 11 2020
medline: 13 11 2020
Statut: epublish

Résumé

The establishment of patient-centered measures capable of empirically determining meaningful cognitive change after surgery can significantly improve the medical care of epilepsy patients. Thus, this study aimed to develop reliable change indices (RCIs) and standardized regression-based (SRB) change norms for a comprehensive neuropsychological test battery in the German language. Forty-seven consecutive patients with temporal lobe epilepsy underwent neuropsychological assessments, both before and 12 months after surgery. Practice-effect-adjusted RCIs and SRB change norms for each test score were computed. To assess their usefulness, the presented methods were applied to a clinical sample, and binary logistic regression analyses were conducted to model the odds of achieving improvement in quality of life (QOL) after surgery. The determined RCIs at 90% confidence intervals and the SRB equations for each test score included in the test battery are provided. Cohen's kappa analyses revealed a moderate mean agreement between the two measures, varying from slight to almost perfect agreement across test scores. Using these measures, a negative association between improvement in QOL and decline in verbal memory functions after surgery was detected (adjusted odds ratio = 0.09, To the best of our knowledge, this study is the first to develop RCIs and SRB change norms necessary for the objective determination of neuropsychological change in a comprehensive test battery in the German language, facilitating the individual monitoring of improvement and decline in each patients' cognitive functioning and psychosocial situations after epilepsy surgery. The application of the described measures revealed a strong negative association between improvement in QOL and decline in verbal memory functions after surgery.

Identifiants

pubmed: 33178083
doi: 10.3389/fpsyg.2020.582836
pmc: PMC7593256
doi:

Types de publication

Journal Article

Langues

eng

Pagination

582836

Informations de copyright

Copyright © 2020 Conradi, Behrens, Hermsen, Kannemann, Merkel, Schuster, Freiman, Strzelczyk and Rosenow.

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Auteurs

Nadine Conradi (N)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.

Marion Behrens (M)

Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.

Anke M Hermsen (AM)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.

Tabitha Kannemann (T)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.

Nina Merkel (N)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.

Annika Schuster (A)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.

Thomas M Freiman (TM)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.
Department of Neurosurgery, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.

Adam Strzelczyk (A)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.

Felix Rosenow (F)

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt, Germany.
LOEWE Center for Personalized Translational Epilepsy Research, Goethe University, Frankfurt, Germany.

Classifications MeSH