Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity.
amphotericin B
oral delivery
paromomycin
solid lipid nanoparticles
visceral leishmaniasis
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2020
accepted:
09
09
2020
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
22
6
2021
Statut:
epublish
Résumé
The design and development of new pharmaceutical formulations for the existing anti-leishmanial is a new strategic alternate to improve efficacy and safety rather than new drug discovery. Herein hybrid solid lipid nanoparticles (SLN) have been engineered to direct the oral delivery of two anti-leishmanial drugs amphotericin B (AmB) and paromomycin (PM). The combinatorial nanocarriers consist of conventional SLN, antileishmanial drugs (AmB and PM) which have been functionalized with chitosan (Cs) grafted onto the external surface. The Cs-SLN have the mean particle size of 373.9 ± 1.41 nm, polydispersity index (PDI) of 0.342 ± 0.02 and the entrapment efficiency for AmB and PM was found to be 95.20 ± 3.19% and 89.45 ± 6.86 %, respectively. Characterization of SLN was performed by scanning electron microscopy and transmission electron microscopy. Complete internalization of the formulation was observed in Caco-2 cells. Cs-SLN has shown a controlled and slow drug release profile over a period of 72 h and was stable at gastrointestinal fluids, confirmed by simulated gastro-intestinal fluids study. Cs coating enhanced the mucoadhesive property of Cs-SLN.
Identifiants
pubmed: 33178626
doi: 10.3389/fcimb.2020.570573
pmc: PMC7593694
doi:
Substances chimiques
Biological Products
0
Drug Carriers
0
Paromomycin
61JJC8N5ZK
Amphotericin B
7XU7A7DROE
Chitosan
9012-76-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
570573Informations de copyright
Copyright © 2020 Parvez, Yadagiri, Karole, Singh, Verma, Sundar and Mudavath.
Références
Br J Clin Pharmacol. 1983 Jul;16(1):106-8
pubmed: 6882617
Eur J Pharm Biopharm. 2009 Feb;71(2):181-9
pubmed: 18940256
Nat Rev Microbiol. 2007 Nov;5(11):873-82
pubmed: 17938629
Food Sci Biotechnol. 2017 Dec 13;27(2):441-450
pubmed: 30263768
Drug Deliv Transl Res. 2020 Feb;10(1):34-42
pubmed: 31240624
Int J Pharm. 2015 Nov 30;495(2):719-27
pubmed: 26410757
Expert Opin Drug Deliv. 2014 May;11(5):633-46
pubmed: 24606222
J Nanobiotechnology. 2015 Jul 10;13:47
pubmed: 26156035
AAPS PharmSciTech. 2018 Oct;19(7):3152-3164
pubmed: 30136175
Parasitol Res. 2018 Jul;117(7):2323-2326
pubmed: 29717371
Mol Pharm. 2019 Nov 4;16(11):4519-4529
pubmed: 31509418
J Control Release. 2017 Mar 10;249:150-161
pubmed: 28153762
Drug Deliv Transl Res. 2019 Aug;9(4):816-827
pubmed: 30924025
Pharm Res. 2003 Nov;20(11):1812-9
pubmed: 14661926
J Drug Target. 2011 May;19(4):239-50
pubmed: 20545446
Lipids Health Dis. 2012 Jun 13;11:72
pubmed: 22695222
AAPS PharmSciTech. 2017 Apr;18(3):875-883
pubmed: 27368922
J Nanobiotechnology. 2018 Sep 19;16(1):71
pubmed: 30231877
Colloids Surf B Biointerfaces. 2016 Mar 1;139:17-24
pubmed: 26700229
Antimicrob Agents Chemother. 2014 May;58(5):2608-13
pubmed: 24550333
Drugs. 2013 Nov;73(17):1863-88
pubmed: 24170666
Ther Adv Infect Dis. 2016 Jun;3(3-4):98-109
pubmed: 27536354
Pharm Res. 1997 Jul;14(7):923-9
pubmed: 9244151
J Microencapsul. 2010;27(1):78-85
pubmed: 19538034
AAPS PharmSciTech. 2007 Oct 12;8(4):E83
pubmed: 18181544
Pharm Res. 2015 Oct;32(10):3282-92
pubmed: 25968624
Emerg Infect Dis. 2012 Oct;18(10):1662-4
pubmed: 23017164
Eur J Pharm Sci. 2018 Mar 1;114:103-113
pubmed: 29229273
AAPS J. 2010 Sep;12(3):397-406
pubmed: 20458565
Food Funct. 2013 Sep;4(9):1410-9
pubmed: 23921424
Nanoscale Res Lett. 2016 Dec;11(1):524
pubmed: 27888498
Appl Biochem Biotechnol. 2014 Oct;174(4):1309-1330
pubmed: 25106894
PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052
pubmed: 29240765
AAPS PharmSciTech. 2011 Mar;12(1):192-200
pubmed: 21194014
Int J Pharm. 2003 Jul 24;260(2):167-73
pubmed: 12842337
AAPS PharmSciTech. 2019 Mar 5;20(3):136
pubmed: 30838459
BMC Infect Dis. 2019 Aug 27;19(1):747
pubmed: 31455227
Infect Dis Poverty. 2016 Mar 08;5:19
pubmed: 26951132
Sci Rep. 2017 Jan 23;7:41322
pubmed: 28112262
Colloids Surf B Biointerfaces. 2011 Jul 1;85(2):145-52
pubmed: 21440424
Drug Deliv Transl Res. 2013 Oct;3(5):402-8
pubmed: 25788348
J Parasit Dis. 2019 Jun;43(2):176-185
pubmed: 31263321