The Bone Morphogenetic Protein Pathway: The Osteoclastic Perspective.
bone fracture healing
bone morphogenetic proteins
bone resorption
osteoblast-osteoclast coupling
osteoclasts
recombinant BMP therapy
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
07
2020
accepted:
29
09
2020
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Bone health crucially relies on constant bone remodeling and bone regeneration, both tightly controlled processes requiring bone formation and bone resorption. Plenty of evidence identifies bone morphogenetic proteins (BMP) as major players in osteoblast differentiation and thus, bone formation. However, in recent past years, researchers also increasingly reported on the pivotal role of these multi-functional growth factors in osteoclast formation and activity. This review aims to summarize the current knowledge of BMP signaling within the osteoclast lineage, its role in bone resorption, and osteoblast-osteoclast coupling. Furthermore, subsequent clinical implications for recombinant BMP therapy will be discussed in view of recent preclinical and clinical studies.
Identifiants
pubmed: 33178699
doi: 10.3389/fcell.2020.586031
pmc: PMC7597383
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
586031Informations de copyright
Copyright © 2020 Lademann, Hofbauer and Rauner.
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