Gastro-esophageal reflux disease and Barrett's esophagus: an overview with an histologic diagnostic approach.


Journal

Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 29 06 2020
accepted: 29 06 2020
entrez: 12 11 2020
pubmed: 13 11 2020
medline: 25 8 2021
Statut: ppublish

Résumé

The first part of this overview on non-neoplastic esophagus is focused on gastro-esophageal reflux disease (GERD) and Barrett's esophagus. In the last 20 years much has changed in histological approach to biopsies of patients with gastro-esophageal reflux disease. In particular, elementary histologic lesions have been well defined and modality of evaluation and grade are detailed, their sensitivity and specificity has been evaluated and their use has been validated by several authors. Also if there is not a clinical indication to perform biopsies in patient with GERD, the diagnosis of microscopic esophagitis, when biopsies are provided, can be performed by following simple rules for evaluation which allow pathologists to make the diagnosis with confidence. On the other hand, biopsies are required for the diagnosis of Barrett's esophagus. This diagnosis is the synthesis of endoscopic picture (which has to be provided with the proper description on extent and with adequate biopsies number) and histologic pattern. The current guidelines and expert opinions for the correct management of these diagnosis are detailed.

Identifiants

pubmed: 33179616
doi: 10.32074/1591-951X-162
pmc: PMC7931578
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

117-127

Informations de copyright

Copyright © 2020 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.

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Auteurs

Luca Mastracci (L)

Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Anatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Italy.

Federica Grillo (F)

Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Anatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Italy.

Paola Parente (P)

Unit of Pathology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, (FG), Italy.

Elettra Unti (E)

UOC Anatomia Patologica, ARNAS Ospedali Civico-Di Cristina-Benfratelli, Palermo, Italy.

Serena Battista (S)

SOC di Anatomia Patologica, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.

Paola Spaggiari (P)

Department of Pathology, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.

Michela Campora (M)

Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.

Giulia Scaglione (G)

Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.

Matteo Fassan (M)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Italy.

Roberto Fiocca (R)

Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Anatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Italy.

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