Utility of stimulus induced after discharges in the evaluation of peripheral nerve hyperexcitability: Old wine in a new bottle?
Action Potentials
/ physiology
Adult
Electrodiagnosis
/ methods
Electromyography
Female
Follow-Up Studies
Humans
Isaacs Syndrome
/ diagnosis
Male
Middle Aged
Muscular Diseases
/ diagnosis
Myokymia
/ diagnosis
Neural Conduction
/ physiology
Peripheral Nervous System Diseases
/ diagnosis
Retrospective Studies
Tibial Nerve
/ physiology
contactin-associated protein-2
nerve conduction studies
peripheral nerve hyperexcitability
stimulus-induced after discharge
voltage-gated potassium channel
Journal
Journal of the peripheral nervous system : JPNS
ISSN: 1529-8027
Titre abrégé: J Peripher Nerv Syst
Pays: United States
ID NLM: 9704532
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
04
08
2020
revised:
01
10
2020
accepted:
05
11
2020
pubmed:
13
11
2020
medline:
6
11
2021
entrez:
12
11
2020
Statut:
ppublish
Résumé
Limited literature is available on stimulus induced after discharges (SIAD) in patients with peripheral nerve hyperexcitability (PNH). The aim of the study was to examine the diagnostic utility of SIAD in the diagnosis and monitoring of primary PNH disorders. In this retrospective study, we studied 26 patients who were admitted with a diagnosis of primary PNH to the department of Neurology from January 2013 to April 2019. Their clinical profile, immunological characteristics were extracted from the database and nerve conduction studies were relooked for the presence of SIAD. 76% of patients in the primary PNH cohort had SIAD with 90% of them being voltage-gated potassium channel complex antibody positive; predominantly against contactin-associated protein-2 antigen and rest being paraneoplastic. There was also resolution of SIAD following treatment indicating reversible hyperexcitability. SIAD is a sensitive marker for Primary PNH syndrome with monitoring and diagnostic implications.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-98Informations de copyright
© 2020 Peripheral Nerve Society.
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