New insights into the function of mammalian Argonaute2.
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
Identifiants
pubmed: 33180792
doi: 10.1371/journal.pgen.1009058
pii: PGENETICS-D-20-00720
pmc: PMC7660459
doi:
Substances chimiques
AGO2 protein, human
0
Argonaute Proteins
0
MicroRNAs
0
RNA, Guide
0
RNA, Messenger
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1009058Déclaration de conflit d'intérêts
The author has declared that no competing interests exist.
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