Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.
Animals
Autoimmunity
Biomarkers
/ metabolism
Cytokines
/ immunology
Dopaminergic Neurons
/ immunology
Humans
Inflammation
/ immunology
Microglia
/ immunology
Nerve Degeneration
/ immunology
Parkinson Disease
/ etiology
Parkinsonian Disorders
/ etiology
Signal Transduction
Virus Diseases
/ complications
alpha-Synuclein
/ immunology
Parkinson’s
autoimmunity
neurodegeneration
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Nov 2020
10 Nov 2020
Historique:
received:
20
09
2020
revised:
30
10
2020
accepted:
06
11
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
6
5
2021
Statut:
epublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated mechanisms are pivotal to the pathogenicity and progression of the disease. In this review, we highlight the binary role of microglia activation in the pathophysiology of the disorder, both neuroprotective and neuromodulatory. We present how the expression of several cytokines implicated in dopaminergic neurons (DA) degeneration could be used as biomarkers for PD. Viral infections have been studied and correlated to the disease progression, usually operating as trigger factors for the inflammatory process. The gut-brain axis and the possible contribution of the peripheral bowel inflammation to neuronal death, mainly dopaminergic neurons, seems to be a main contributor of brain neuroinflammation. The role of the immune system has also been analyzed implicating a-synuclein in the activation of innate and adaptive immunity. We also discuss therapeutic approaches concerning PD and neuroinflammation, which have been studied in experimental and in vitro models and data stemming from epidemiological studies.
Identifiants
pubmed: 33182554
pii: ijms21228421
doi: 10.3390/ijms21228421
pmc: PMC7697354
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
alpha-Synuclein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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