Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability.
deficient mismatch repair
gynecological cancers
microsatellite instability
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Nov 2020
10 Nov 2020
Historique:
received:
11
09
2020
revised:
30
10
2020
accepted:
07
11
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
14
11
2020
Statut:
epublish
Résumé
Mutations in mismatch repair genes leading to mismatch repair (MMR) deficiency (dMMR) and microsatellite instability (MSI) have been implicated in multiple types of gynecologic malignancies. Endometrial carcinoma represents the largest group, with approximately 30% of these cancers caused by dMMR/MSI. Thus, testing for dMMR is now routine for endometrial cancer. Somatic mutations leading to dMMR account for approximately 90% of these cancers. However, in 5-10% of cases, MMR protein deficiency is due to a germline mutation in the mismatch repair genes
Identifiants
pubmed: 33182707
pii: cancers12113319
doi: 10.3390/cancers12113319
pmc: PMC7697596
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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