Childhood Epilepsy with Centrotemporal Spikes: Clinical and Neuropsychological Outcomes 5 Years after Remission.
cognitive
epilepsy with centrotemporal spikes
long-term predictors
neuropsychological
outcome
rolandic
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
10 Nov 2020
10 Nov 2020
Historique:
received:
06
10
2020
revised:
23
10
2020
accepted:
06
11
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
14
11
2020
Statut:
epublish
Résumé
Although specific neuropsychological deficits have been recognized during the active phase of epilepsy with centrotemporal spikes (ECTS), the natural cognitive and neuropsychological history after remission has not been elucidated so far. We evaluated the natural cognitive and neuropsychological outcomes five years after disease remission and investigated possible predictors of long-term outcome among socio-demographic and electro-clinical variables. We performed an observational cross-sectional study. Electro-clinical characteristics during the active phase of epilepsy, as well as antiepileptic treatment and premorbid neurodevelopmental concerns were reviewed for 70 patients. At least five years after epilepsy remission, all patients were contacted, and 46 completed a structured questionnaire about patients' current education and academic skills, general health, and parents' socio-economic status. Among them, 23 patients underwent an ad hoc cognitive and neuropsychological protocol and emotional-behavioral assessment. Chi-square tests and
Identifiants
pubmed: 33182826
pii: diagnostics10110931
doi: 10.3390/diagnostics10110931
pmc: PMC7696372
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : RC 2017-2019
Déclaration de conflit d'intérêts
Dr. De Giorgis received a paid consultancy from Nutricia Gmbh. Dr. Varesio received a paid consultancy from GLUT1 Italian association Onlus. Prof. Veggiotti received economic support (speaker fee, travel expenses) from Nutricia GmbH, Dr. Schär AG/SPA, Eisai. None of the other authors has a conflict of interest to disclosure.
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