Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
received:
16
06
2020
accepted:
22
07
2020
revised:
29
06
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA methylation sites associated with ADHD symptoms at two methylation assessment periods: birth and school age. We examined associations of both DNA methylation in cord blood with repeatedly assessed ADHD symptoms (age 4-15 years) in 2477 children from 5 cohorts and of DNA methylation at school age with concurrent ADHD symptoms (age 7-11 years) in 2374 children from 9 cohorts, with 3 cohorts participating at both timepoints. CpGs identified with nominal significance (p < 0.05) in either of the EWAS were correlated between timepoints (ρ = 0.30), suggesting overlap in associations; however, top signals were very different. At birth, we identified nine CpGs that predicted later ADHD symptoms (p < 1 × 10
Identifiants
pubmed: 33184255
doi: 10.1038/s41398-020-01058-z
pii: 10.1038/s41398-020-01058-z
pmc: PMC7665047
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
398Subventions
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/S009310/1
Pays : International
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R21 ES014947
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)
ID : MS14/00108, CP14/00108
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK085173
Pays : United States
Organisme : RCUK | Economic and Social Research Council (ESRC)
ID : ES/S013229/1
Pays : International
Organisme : Medical Research Council
ID : MR/S036520/1
Pays : United Kingdom
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_UU_00011/5
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
ID : 016.VICI.170.200
Pays : International
Organisme : Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)
ID : MS13/00054, CP18/00018
Pays : International
Organisme : NIEHS NIH HHS
ID : R24 ES028531
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
ID : 024.001.003
Pays : International
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