Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
received:
20
08
2020
accepted:
28
10
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.
Identifiants
pubmed: 33184353
doi: 10.1038/s41598-020-76438-y
pii: 10.1038/s41598-020-76438-y
pmc: PMC7665057
doi:
Substances chimiques
Biomarkers
0
Circulating MicroRNA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19620Références
Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E723-E733
pubmed: 29969318
J Immunol. 2016 Jun 1;196(11):4477-86
pubmed: 27183592
Asian Pac J Allergy Immunol. 2016 Dec;34(4):300-305
pubmed: 27001659
Clin Diagn Lab Immunol. 2005 Jan;12(1):52-5
pubmed: 15642984
Immunology. 2015 Jan;144(1):1-10
pubmed: 25093579
Clin Transl Sci. 2012 Feb;5(1):32-8
pubmed: 22376254
J Alzheimers Dis Parkinsonism. 2018;8(1):
pubmed: 29862137
J Transl Med. 2016 Jul 26;14(1):219
pubmed: 27456854
Blood. 2016 Jan 14;127(2):187-99
pubmed: 26537302
Biochimie. 2007 Jun-Jul;89(6-7):789-98
pubmed: 17400356
Curr Genomics. 2010 Nov;11(7):537-61
pubmed: 21532838
Eur J Immunol. 2016 Mar;46(3):725-31
pubmed: 26639063
PLoS One. 2016 Mar 11;11(3):e0150904
pubmed: 26967895
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7080-5
pubmed: 17438277
J Clin Sleep Med. 2012 Dec 15;8(6):719-28
pubmed: 23243408
Biopsychosoc Med. 2019 Dec 2;13:29
pubmed: 31827600
J Immunol. 2016 Dec 15;197(12):4829-4837
pubmed: 27807190
Hum Immunol. 2011 Jun;72(6):470-8
pubmed: 21406206
Transplantation. 2010 Jul 27;90(2):105-12
pubmed: 20574417
Diagnostics (Basel). 2019 Jul 20;9(3):
pubmed: 31330791
Int Immunopharmacol. 2019 Oct;75:105778
pubmed: 31494340
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1536-44
pubmed: 26903630
Sci Rep. 2017 Nov 10;7(1):15338
pubmed: 29127316
J Biol Chem. 2010 Mar 5;285(10):7006-15
pubmed: 20007695
Clin Hemorheol Microcirc. 2019;71(1):113-116
pubmed: 30594919
Expert Rev Clin Pharmacol. 2016 Jun;9(6):755-70
pubmed: 27045557
PLoS One. 2014 Sep 19;9(9):e102783
pubmed: 25238588
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9607-12
pubmed: 23690573
Eur J Immunol. 2012 Oct;42(10):2760-70
pubmed: 22777911
Front Pediatr. 2019 Jan 08;6:412
pubmed: 30671425
J Immunol. 2006 May 15;176(10):5925-33
pubmed: 16670300
Front Physiol. 2020 Jun 10;11:605
pubmed: 32587527
J Neurol Neurobiol. 2015 Sep;1(4):
pubmed: 27088131
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
Sci Rep. 2020 Feb 7;10(1):2064
pubmed: 32034172
J Psychosom Res. 1995 Apr;39(3):315-25
pubmed: 7636775
J Cell Mol Med. 2020 May;24(10):5865-5877
pubmed: 32291908
Int Rev Cell Mol Biol. 2017;334:309-343
pubmed: 28838542
Curr Neuropharmacol. 2015;13(5):701-34
pubmed: 26411464
Cancer Cell. 2006 Jun;9(6):435-43
pubmed: 16766263
Int J Genomics. 2017;2017:6218353
pubmed: 29349062
Cells. 2020 Jan 23;9(2):
pubmed: 31979244
Sci Rep. 2019 May 17;9(1):7527
pubmed: 31101833
Sci Rep. 2016 Feb 01;6:20176
pubmed: 26833392
J Transl Med. 2015 Sep 14;13:299
pubmed: 26370228
Diagnostics (Basel). 2019 Aug 07;9(3):
pubmed: 31394725
J Affect Disord. 2012 Dec 10;141(2-3):261-9
pubmed: 22572093
Exerc Immunol Rev. 2014;20:135-64
pubmed: 24974725
Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1162-H1167
pubmed: 28916639
Front Cell Neurosci. 2013 Dec 19;7:265
pubmed: 24391543
Front Genet. 2016 Nov 15;7:196
pubmed: 27895662
Front Mol Biosci. 2017 Jun 06;4:38
pubmed: 28634583