Effect of Japanese herbal Kampo medicines on live birth rate in women with recurrent pregnancy loss.
Cohort study
Japanese herbal Kampo medicine
Live birth rate
Propensity score matching
Recurrent pregnancy loss
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
10
09
2020
received:
06
05
2020
accepted:
11
11
2020
pubmed:
14
11
2020
medline:
22
6
2021
entrez:
13
11
2020
Statut:
ppublish
Résumé
To determine the effectiveness of Japanese Kampo medicines on the overall live birth rate among patients with recurrent pregnancy loss (RPL) in a real-world setting. In the current retrospective cohort study, we used the JMDC Claims Database to extract information on women diagnosed with RPL between January 1, 2005 and August 31, 2018. Eligible women were divided into two groups according to Kampo medicines administered as treatments for RPL. The primary outcome was the live birth rate during the study period. Propensity score matching, Kaplan-Meier cumulative incidence plots, log-rank test, and Cox proportional-hazards regression model were used to compare the primary outcome between patients with and without Japanese herbal Kampo medicines. Among 5517 eligible patients, 1652 used Kampo medicines and 3865 did not. After propensity score matching, the live birth rate at 2.0 years was 15.7% in the Kampo group and 11.2% in the non-Kampo group. At 4.0 years, the difference between the two groups had slightly increased. The overall live birth rate differed significantly between the two groups (hazard ratio 1.32, 95% confidence interval 1.13-1.53; P < 0.001). Japanese herbal Kampo medicines may improve the live birth rate in patients with RPL.
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
489-495Subventions
Organisme : Ministry of Health, Labour and Welfare, Japan
ID : 19AA2007
Organisme : Ministry of Education, Culture, Sports, Science, and Technology, Japan
ID : 20H03907
Organisme : Ministry of Education, Culture, Sports, Science, and Technology, Japan
ID : 17H05077
Informations de copyright
© 2020 International Federation of Gynecology and Obstetrics.
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