Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [
Autoradiography
Grooming
Obsessive–compulsive disorder (OCD)
Positron emission tomography (PET)
SAP90/PSD-95-associated protein 3 (Sapap3)
Synaptic vesicle protein 2A (SV2A)
[11C]UCB-J
[3H]UCB-J
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
13 Nov 2020
13 Nov 2020
Historique:
received:
24
07
2020
accepted:
20
10
2020
entrez:
13
11
2020
pubmed:
14
11
2020
medline:
14
11
2020
Statut:
epublish
Résumé
Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders-including obsessive-compulsive disorder (OCD)-is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([ Longitudinal [ At the age of 3 months, Sapap3 ko mice are already characterized by a significantly lower SV2A availability compared to wt littermates (i.a. cortex - 12.69%, p < 0.01; striatum - 14.12%, p < 0.001, thalamus - 13.11%, p < 0.001, and hippocampus - 12.99%, p < 0.001). Healthy ageing in control mice was associated with a diffuse and significant (p < 0.001) decline throughout the brain, whereas in Sapap3 ko mice this decline was more confined to the corticostriatal level. A strong linear relationship (p < 0.0001) was established between the outcome parameters of [ [
Sections du résumé
BACKGROUND
BACKGROUND
Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders-including obsessive-compulsive disorder (OCD)-is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([
METHODS
METHODS
Longitudinal [
RESULTS
RESULTS
At the age of 3 months, Sapap3 ko mice are already characterized by a significantly lower SV2A availability compared to wt littermates (i.a. cortex - 12.69%, p < 0.01; striatum - 14.12%, p < 0.001, thalamus - 13.11%, p < 0.001, and hippocampus - 12.99%, p < 0.001). Healthy ageing in control mice was associated with a diffuse and significant (p < 0.001) decline throughout the brain, whereas in Sapap3 ko mice this decline was more confined to the corticostriatal level. A strong linear relationship (p < 0.0001) was established between the outcome parameters of [
CONCLUSIONS
CONCLUSIONS
[
Identifiants
pubmed: 33185747
doi: 10.1186/s13550-020-00721-2
pii: 10.1186/s13550-020-00721-2
pmc: PMC7666267
doi:
Types de publication
Journal Article
Langues
eng
Pagination
140Subventions
Organisme : Universiteit Antwerpen
ID : 41/FA020000/FFB140317
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 42/FA020000/685
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