Combination of resistance and aerobic exercise for six months improves bone mass and physical function in HIV infected individuals: A randomized controlled trial.
Adiponectin
/ blood
Adult
Biomarkers
/ blood
Body Mass Index
Bone Density
/ physiology
Female
Fibronectins
/ blood
HIV Infections
/ physiopathology
Hand Strength
Humans
Insulin-Like Growth Factor I
/ metabolism
Interleukin-6
/ blood
Male
Middle Aged
Myostatin
/ blood
Physical Conditioning, Human
/ methods
Physical Functional Performance
Resistance Training
Single-Blind Method
Tumor Necrosis Factor-alpha
/ blood
Walking Speed
HIV
HIV related bone loss
antiretroviral therapy
combined training
wasting syndrome
Journal
Scandinavian journal of medicine & science in sports
ISSN: 1600-0838
Titre abrégé: Scand J Med Sci Sports
Pays: Denmark
ID NLM: 9111504
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
29
05
2020
revised:
28
10
2020
accepted:
04
11
2020
pubmed:
14
11
2020
medline:
16
6
2021
entrez:
13
11
2020
Statut:
ppublish
Résumé
To evaluate the effect of combined resistance and aerobic training (RT+AT) on regional bone mineral density (BMD) and physical performance in people living with HIV (PLWH). Forty PLWH (20 men and 20 women) were randomized into RT+AT group (n = 20; age = 38.3 ± 4.9) or non-exercise control group (n = 20; age = 37.9 ± 5.1). The RT+AT group was required to perform a nonlinear periodized resistance training program targeting large muscle groups followed by 20 min aerobic exercise at 65-80% of maximal heart rate. Participants in RT+AT performed three supervised sessions per week for 6-months, whereas participants in the control group were instructed to continue with their current lifestyle habits. The primary outcome was bone mineral density (lumbar spine (L2-L4), femoral neck, and distal 1/3 radius). Secondary outcomes included physical function, anthropometry, inflammatory markers, and growth factors. The RT+AT group demonstrated a significant increase in BMD at follow-up for the Lumbar spine (L2-L4), femoral neck, and 1/3 radius (all, P < .05), and There were no gender differences in the training response between men and women for any of the BMD regions. Similar findings were also observed for lean body mass, IGF1and Adiponectin (P < .001). We observed a decrease in percent body fat, fat mass, IL-6, TNF-α, and myostatin in the RT+AT group (P < .001). Finally, there was a significant increase in handgrip strength and gait speed for both women and men in the RT+AT group (P < .001). A combination of resistance and aerobic training appears to be a feasible and effective means for counteracting bone loss and improving various inflammatory markers, physical function, and growth hormones in PLWH.
Substances chimiques
Adiponectin
0
Biomarkers
0
FNDC5 protein, human
0
Fibronectins
0
IGF1 protein, human
0
IL6 protein, human
0
Interleukin-6
0
Myostatin
0
Tumor Necrosis Factor-alpha
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
720-732Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Bonjoch A, Figueras M, Estany C, et al. High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study. Aids. 2010;24(18):2827-2833.
Ofotokun I, Weitzmann MN. HIV and bone metabolism. Discovery medicine. 2011;11(60):385.
Walker Harris V, Brown TT. Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies. J Infect Dis. 2012;205(suppl_3):S391-S398.
Ofotokun I, McIntosh E, Weitzmann MN. HIV: inflammation and bone. Curr HIV/AIDS Rep. 2012;9(1):16-25.
Perazzo JD, Webel AR, Fichtenbaum CJ, McComsey GA. Bone health in people living with HIV: the role of exercise and directions for future research. J Assoc Nurses AIDS Care. 2018;29(2):330-337.
Ali MK, Magee MJ, Dave JA, et al. HIV and metabolic, body, and bone disorders: what we know from low-and middle-income countries. JAIDS J Acquir Immune Defic Syndr. 2014;67:S27-S39.
Edelman EJ, Rentsch CT, Justice AC. Polypharmacy in HIV: recent insights and future directions. Curr Opin HIV AIDS. 2020;15(2):126-133.
Turner CH, Robling AG. Designing exercise regimens to increase bone strength. Exerc Sport Sci Rev. 2003;31(1):45-50.
Benedetti MG, Furlini G, Zati A, Letizia MG. The effectiveness of physical exercise on bone density in osteoporotic patients. Biomed Res Int. 2018;2018:1-10.
Howe TE, Shea B, Dawson LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2011;7:1-37.
Fuchs RK, Bauer JJ, Snow CM. Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res. 2001;16(1):148-156.
Hinton PS, Nigh P, Thyfault J. Effectiveness of resistance training or jumping-exercise to increase bone mineral density in men with low bone mass: a 12-month randomized, clinical trial. Bone. 2015;79:203-212.
Fillipas S, Cherry C, Cicuttini F, Smirneos L, Holland A. The effects of exercise training on metabolic and morphological outcomes for people living with HIV: a systematic review of randomised controlled trials. HIV Clin Trials. 2010;11(5):270-282.
Nosrat S, Whitworth JW, Ciccolo JT. Exercise and mental health of people living with HIV: a systematic review. Chronic illness. 2017;13(4):299-319.
Malita FM, Karelis AD, Toma E, Rabasa-Lhoret R. Effects of different types of exercise on body composition and fat distribution in HIV-infected patients: a brief review. Can J Appl Physiol. 2005;30(2):233-245.
Noble BJ, Borg GA, Jacobs I, Ceci R, Kaiser P. A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate. Med Sci Sports Exerc. 1983;15(6):523.
Pescatello LS, Riebe D, Thompson PD. ACSM's guidelines for exercise testing and prescription. Baltimore, MD: Lippincott Williams & Wilkins; 2014.
Zanetti HR, da Cruz LG, Lourenço CLM, et al. Nonlinear resistance training enhances the lipid profile and reduces inflammation marker in people living with HIV: a randomized clinical trial. J Phys Act Health. 2016;13(7):765-770.
Lasevicius T, Ugrinowitsch C, Schoenfeld BJ, et al. Effects of different intensities of resistance training with equated volume load on muscle strength and hypertrophy. Euro J Sport Sci. 2018;18(6):772-780.
Mj K. The Effects of Training on Heart Rate; A Longitudinal Study. Paper presented at: Annales Medicinae Experimentalis et Biologiae Fenniae; 1957.
Alexandre TS, Meira DM, Rico NC, Mizuta SK. Accuracy of timed up and go test for screening risk of falls among community-dwelling elderly. Brazilian J Phys Ther. 2012;16(5):381-388.
Santos WR, Santos WR, Paes PP, et al. Impact of strength training on bone mineral density in patients infected with HIV exhibiting lipodystrophy. J Strength Cond Res. 2015;29(12):3466-3471.
Chaplais E, Thivel D, Greene D, et al. Bone-adiposity cross-talk: implications for pediatric obesity. J Bone Miner Metab. 2015;33(6):592-602.
Picca A, Calvani R, Manes-Gravina E, et al. Bone-muscle crosstalk: unraveling new therapeutic targets for osteoporosis. Curr Pharm Des. 2017;23(41):6256-6263.
O’Brien KK, Tynan A-M, Nixon SA, Glazier RH. Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis. 2017;17(1):268.
Ghayomzadeh M, SeyedAlinaghi SA, Shamsi MM, et al. Effect of 8 weeks of hospital-based resistance training program on TCD4+ cell count and anthropometric characteristic of patients with HIV in Tehran, Iran: a randomized controlled trial. J Strength Cond Res. 2019;33(4):1146-1155.
Vingren JL, Curtis JH, Levitt DE, et al. Adding resistance training to the standard of care for inpatient substance abuse treatment in men with human immunodeficiency virus improves skeletal muscle health without altering cytokine concentrations. J Strength Cond Res. 2018;32(1):76-82.
Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607-615.
Jain S, Desai N, Bhangoo A. Pathophysiology of GHRH-growth hormone-IGF1 axis in HIV/AIDS. Rev Endocr Metab Disord. 2013;14(2):113-118.
Frystyk J. Exercise and the growth hormone-insulin-like growth factor axis. Med Sci Sports Exerc. 2010;42(1):58-66.
Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, et al. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci. 1998;95(25):14938-14943.
Elkina Y, von Haehling S, Anker SD, Springer J. The role of myostatin in muscle wasting: an overview. J Cachexia, Sarcopenia Muscle. 2011;2(3):143.
Hittel DS, Axelson M, Sarna N, Shearer J, Huffman KM, Kraus WE. Myostatin decreases with aerobic exercise and associates with insulin resistance. Med Sci Sports Exerc. 2010;42(11):2023.
Lenk K, Erbs S, Höllriegel R, et al. Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. Eur J Prev Cardiol. 2012;19(3):404-411.
Colaianni G, Mongelli T, Colucci S, Cinti S, Grano M. Crosstalk between muscle and bone via the muscle-myokine irisin. Curr Osteoporosis Rep. 2016;14(4):132-137.
Srinivasa S, Wong K, Fitch KV, et al. Effects of lifestyle modification and metformin on irisin and FGF 21 among HIV-infected subjects with the metabolic syndrome. Clin Endocrinol. 2015;82(5):678-685.
Guariglia DA, Pedro RE, Deminice R, Rosa FT, Peres SB, De Moraes SMF. Effect of combined training on body composition and metabolic variables in people living with HIV: a randomized clinical trial. Cytokine. 2018;111:505-510.
Lenchik L, Register TC, Hsu F-C, et al. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003;33(4):646-651.
Kinlaw WB, Marsh B. Adiponectin and HIV-lipodystrophy: taking HAART. Endocrinology. 2004;145(2):484-486.
Chou C-H, Hwang C-L, Wu Y-T. Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. Arch Phys Med Rehabil. 2012;93(2):237-244.
Mikkelsen MK, Juhl CB, Lund CM, Jarden M, Vinther A, Nielsen DL. The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review. Euro Rev Aging Phys Activity. 2020;17(1):1-15.
Bohannon RW. Grip strength: an indispensable biomarker for older adults. Clin Interv Aging. 2019;14:1681.
Erlandson KM, Allshouse AA, Jankowski CM, Mawhinney S, Kohrt WM, Campbell TB. Relationship of physical function and quality of life among persons aging with HIV infection. AIDS (London, England). 2014;28(13):1939.
Erlandson KM, MaWhinney S, Wilson M, et al. Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection. AIDS (London, England). 2018;32(16):2317.
Dostanpor A, Dobson CA, Vanicek N. Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density. Gait Posture. 2018;64:230-237.