Three-dimensionally two-photon lithography realized vascular grafts.
3D fabrication
endothelial cells
microstructured scaffolds
two-photon laser lithography
vascular tissue engineering
Journal
Biomedical materials (Bristol, England)
ISSN: 1748-605X
Titre abrégé: Biomed Mater
Pays: England
ID NLM: 101285195
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
30
10
2020
accepted:
13
11
2020
pubmed:
14
11
2020
medline:
1
4
2022
entrez:
13
11
2020
Statut:
epublish
Résumé
Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.
Identifiants
pubmed: 33186926
doi: 10.1088/1748-605X/abca4b
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Creative Commons Attribution license.