Metabolomics of Interstitial Fluid, Plasma and Urine in Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms.
1H NMR spectroscopy
biomarkers
interstitial fluid
lymphatic system
metabolic phenotyping
prenodal lymph
primary hypertension
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Nov 2020
11 Nov 2020
Historique:
received:
17
09
2020
revised:
07
11
2020
accepted:
09
11
2020
entrez:
14
11
2020
pubmed:
15
11
2020
medline:
15
11
2020
Statut:
epublish
Résumé
There is growing evidence that lymphatic system plays a pivotal role in the pathogenesis of hypertension. Here, for the first time, the metabolome of interstitial fluid is analyzed in patients with arterial hypertension. Due to ethical issues to obtain human interstitial fluid samples, this study included only oncological patients after axillary lymph node dissection (ALND). These patients were matched into hypertensive (n = 29) and normotensive (n = 35) groups with similar oncological status. Simultaneous evaluation of interstitial fluid, plasma, and urine was obtained by combining high-resolution proton nuclear magnetic resonance (
Identifiants
pubmed: 33187152
pii: diagnostics10110936
doi: 10.3390/diagnostics10110936
pmc: PMC7698256
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Wroclaw Medical University Grant
ID : ST.E220.17.047
Organisme : the Knut and Alice Wallenberg foundation
ID : ("NMR for Life" Programme)
Organisme : the Kempe Foundation, the SciLifeLab
ID : (Swedish NMR Centre)
Organisme : the Swedish Research Council
ID : and the Swedish Cancer Foundation
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