Age differences in the relationships between risk factors and loss of kidney function: a general population cohort study.
Adult
Age Factors
Aged
Aged, 80 and over
Cardiovascular Diseases
/ complications
Diabetes Complications
Female
Glomerular Filtration Rate
Humans
Hypertension
/ complications
Male
Middle Aged
Proteinuria
/ complications
Renal Insufficiency, Chronic
/ etiology
Retrospective Studies
Risk Factors
Smoking
/ adverse effects
Aged
Chronic renal insufficiency
Glomerular filtration rate
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
15
07
2020
accepted:
22
10
2020
entrez:
14
11
2020
pubmed:
15
11
2020
medline:
3
11
2021
Statut:
epublish
Résumé
Annual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear. A community-based retrospective cohort study of adults who underwent annual medical examinations between 1999 and 2013 was conducted. The participants were stratified into different age groups (40-49, 50-59, 60-69, 70-79, and ≥ 80 years) to assess the risk for loss of kidney function. A mixed-effects model was used to estimate the association between risk factors and annual changes in eGFR. In total, 51,938 participants were included in the analysis. The age group of ≥80 years included 8127 individuals. The mean annual change in eGFR was - 0.39 (95% confidence interval: - 0.41 to - 0.37) mL/min/1.73 m Higher systolic blood pressure, proteinuria, and smoking were related to faster loss of kidney function, and a greater effect size was observed in the older participants. More risk assessments for older people are required for personalized care.
Sections du résumé
BACKGROUND
Annual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear.
METHODS
A community-based retrospective cohort study of adults who underwent annual medical examinations between 1999 and 2013 was conducted. The participants were stratified into different age groups (40-49, 50-59, 60-69, 70-79, and ≥ 80 years) to assess the risk for loss of kidney function. A mixed-effects model was used to estimate the association between risk factors and annual changes in eGFR.
RESULTS
In total, 51,938 participants were included in the analysis. The age group of ≥80 years included 8127 individuals. The mean annual change in eGFR was - 0.39 (95% confidence interval: - 0.41 to - 0.37) mL/min/1.73 m
CONCLUSIONS
Higher systolic blood pressure, proteinuria, and smoking were related to faster loss of kidney function, and a greater effect size was observed in the older participants. More risk assessments for older people are required for personalized care.
Identifiants
pubmed: 33187480
doi: 10.1186/s12882-020-02121-z
pii: 10.1186/s12882-020-02121-z
pmc: PMC7664087
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
477Références
Lancet. 2015 May 16;385(9981):1975-82
pubmed: 25777665
PLoS One. 2017 Jul 11;12(7):e0179234
pubmed: 28700596
JAMA. 2012 Dec 12;308(22):2349-60
pubmed: 23111824
Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii77-ii83
pubmed: 28340135
Lancet. 2013 Jul 27;382(9889):339-52
pubmed: 23727170
Am J Epidemiol. 2006 Aug 1;164(3):263-71
pubmed: 16775042
Hypertens Res. 2008 Mar;31(3):485-92
pubmed: 18497468
J Am Soc Nephrol. 2003 Nov;14(11):2934-41
pubmed: 14569104
Am J Kidney Dis. 2014 Jul;64(1):40-8
pubmed: 24613056
Kidney Int. 2006 Jun;69(12):2155-61
pubmed: 16531986
J Am Geriatr Soc. 2009 Dec;57(12):2217-23
pubmed: 20121987
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
Kidney Int. 2007 Jan;71(2):159-66
pubmed: 17136030
Nihon Jinzo Gakkai Shi. 1996 Jul;38(7):296-9
pubmed: 8741390
Nephrol Dial Transplant. 2019 Apr 1;34(4):561-566
pubmed: 29796633
Clin Exp Nephrol. 2009 Dec;13(6):621-30
pubmed: 19513802
BMJ. 2016 Jan 18;352:h6559
pubmed: 26780947
Clin Exp Nephrol. 2017 Jun;21(3):446-456
pubmed: 27412450
Adv Chronic Kidney Dis. 2010 Jul;17(4):302-7
pubmed: 20610357
Kidney Int. 2006 Mar;69(5):823-31
pubmed: 16518341
Lancet Diabetes Endocrinol. 2015 Sep;3(9):704-14
pubmed: 26235959
Clin Exp Nephrol. 2014 Aug;18(4):613-20
pubmed: 24132561
Am J Kidney Dis. 2009 Jun;53(6):950-60
pubmed: 19394727
PLoS One. 2013 Aug 30;8(8):e71810
pubmed: 24147148
Am J Kidney Dis. 2006 Mar;47(3):396-405
pubmed: 16490617
Diabetes Care. 2010 Jan;33 Suppl 1:S62-9
pubmed: 20042775
Stat Med. 2005 Oct 15;24(19):2911-35
pubmed: 16152135
Am J Kidney Dis. 2009 Jun;53(6):982-92
pubmed: 19339088
Clin J Am Soc Nephrol. 2016 Dec 7;11(12):2186-2194
pubmed: 27683625
Diabetes Obes Metab. 2019 May;21(5):1237-1250
pubmed: 30697905
Hypertens Res. 2008 Mar;31(3):433-41
pubmed: 18497462
J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1387-93
pubmed: 22923431
J Am Soc Nephrol. 2019 Sep;30(9):1746-1755
pubmed: 31292199
Clin Exp Nephrol. 2018 Apr;22(2):318-327
pubmed: 28884361
Nephrol Dial Transplant. 2011 Oct;26(10):3286-95
pubmed: 21677301
N Engl J Med. 2015 Nov 26;373(22):2103-16
pubmed: 26551272