Vascular surveillance by haptotactic blood platelets in inflammation and infection.

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
13 11 2020

Historique:

received: 27 12 2019

accepted: 14 10 2020

entrez: 14 11 2020

pubmed: 15 11 2020

medline: 25 11 2020

Statut: epublish

Résumé

Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate platelets form blood-clots during thrombosis, but also play a crucial role in inflammation. While spatio-temporal dynamics of clot formation are well characterized, the cell-biological mechanisms of platelet recruitment to inflammatory micro-environments remain incompletely understood. Here we identify Arp2/3-dependent lamellipodia formation as a prominent morphological feature of immune-responsive platelets. Platelets use lamellipodia to scan for fibrin(ogen) deposited on the inflamed vasculature and to directionally spread, to polarize and to govern haptotactic migration along gradients of the adhesive ligand. Platelet-specific abrogation of Arp2/3 interferes with haptotactic repositioning of platelets to microlesions, thus impairing vascular sealing and provoking inflammatory microbleeding. During infection, haptotaxis promotes capture of bacteria and prevents hematogenic dissemination, rendering platelets gate-keepers of the inflamed microvasculature. Consequently, these findings identify haptotaxis as a key effector function of immune-responsive platelets.

Identifiants

DOI: 10.1038/s41467-020-19515-0 PMID: 33188196 PMC: PMC7666582

pubmed: 33188196

doi: 10.1038/s41467-020-19515-0

pii: 10.1038/s41467-020-19515-0

pmc: PMC7666582

doi:

Substances chimiques

Actin-Related Protein 2-3 Complex 0

Lipopolysaccharides 0

Fibrinogen 9001-32-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

5778

Commentaires et corrections

Type : ErratumIn

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