Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
05
05
2020
accepted:
04
09
2020
entrez:
14
11
2020
pubmed:
15
11
2020
medline:
13
1
2021
Statut:
epublish
Résumé
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
Identifiants
pubmed: 33188205
doi: 10.1038/s41597-020-00716-7
pii: 10.1038/s41597-020-00716-7
pmc: PMC7666191
doi:
Types de publication
Dataset
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
393Subventions
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_UU_12015/1
Pays : International
Organisme : Wellcome Trust (Wellcome)
ID : WT206194
Pays : International
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_UU_12015/5
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/3
Pays : United Kingdom
Références
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Am J Epidemiol. 2013 Oct 1;178(7):1177-84
pubmed: 23863760
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
PLoS Med. 2014 May 20;11(5):e1001647
pubmed: 24845081
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Eur J Hum Genet. 2017 Jun;25(7):854-862
pubmed: 28594416
Nat Genet. 2018 Nov;50(11):1505-1513
pubmed: 30297969
Curr Nutr Rep. 2014;3(4):355-363
pubmed: 25383255
Nature. 2007 Feb 22;445(7130):881-5
pubmed: 17293876
Sci Data. 2020 Nov 13;7(1):393
pubmed: 33188205
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Biostatistics. 2011 Jan;12(1):1-17
pubmed: 20543033
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Diabetologia. 2011 Sep;54(9):2272-82
pubmed: 21717116