Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.
Diabetes
Diabetic retinopathy
Outer retina
Photoreceptors
Phototransduction
RPE
Vasculature
Visual cycle
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
08
08
2020
revised:
27
10
2020
accepted:
31
10
2020
pubmed:
15
11
2020
medline:
15
12
2021
entrez:
14
11
2020
Statut:
ppublish
Résumé
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR.
Identifiants
pubmed: 33188897
pii: S1350-9462(20)30091-4
doi: 10.1016/j.preteyeres.2020.100919
pmc: PMC8113320
mid: NIHMS1647245
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100919Subventions
Organisme : BLRD VA
ID : IK6 BX003604
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY022938
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY033002
Pays : United States
Organisme : NEI NIH HHS
ID : R24 EY024864
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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