Short-duration dynamic FDG PET imaging: Optimization and clinical application.

We aimed to investigate whether short dynamic PET imaging started at injection, complemented with routine clinical acquisition at 60-min post-injection (static), can achieve reliable kinetic analysis. Dynamic and static 18F-2-fluoro-2-deoxy-D-glucose (FDG) PET data were generated using realistic simulations to assess uncertainties due to statistical noise as well as bias. Following image reconstructions, kinetic parameters obtained from a 2-tissue-compartmental model (2TCM) were estimated, making use of the static image, and the time duration of dynamic PET data were incrementally shortened. We also investigated, in the first 2-min, different frame sampling rates, towards optimized dynamic PET imaging. Kinetic parameters from shortened dynamic datasets were additionally estimated for 9 patients (15 scans) with liver metastases of colorectal cancer, and were compared with those derived from full dynamic imaging using correlation and Passing-Bablok regression analyses. The results showed that by reduction of dynamic scan times from 60-min to as short as 5-min, while using static data at 60-min post-injection, bias and variability stayed comparable in estimated kinetic parameters. Early frame samplings of 5, 24 and 30 s yielded highest biases compared to other schemes. An early frame sampling of 10 s generally kept both bias and variability to a minimum. In clinical studies, strong correlation (r ≥ 0.97, P < 0.0001) existed between all kinetic parameters in full vs. shortened scan protocols. Shortened 5-min dynamic scan, sampled as 12 × 10 + 6 × 30 s, followed by 3-min static image at 60-min post-injection, enables accurate and robust estimation of 2TCM parameters, while enabling generation of SUV estimates.

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