Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.

Depressive Disorder, Major Genome-Wide Association Study Humans Multifactorial Inheritance Panic Disorder / genetics Phenotype
Anxiety disorder Depression Intermediate phenotype Loneliness Panic disorder Polygenic risk score

Journal

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390

Informations de publication

Date de publication:
01 2021
Historique:
received: 31 05 2020
revised: 23 09 2020
accepted: 02 11 2020
pubmed: 16 11 2020
medline: 18 1 2022
entrez: 15 11 2020
Statut: ppublish

Résumé

Panic disorder (PD), a common anxiety disorder, is modestly heritable. The genetic basis of anxiety disorders overlaps with that of other psychiatric disorders and their intermediate phenotypes in individuals of European ancestry. Here, we investigated the transethnic polygenetic features shared between Japanese PD patients and European patients with psychiatric disorders and their intermediate phenotypes by conducting polygenic risk score (PRS) analyses. Large-scale European genome-wide association study (GWAS) datasets (n = 7,556-1,131,881) for ten psychiatric disorders and seven intermediate phenotypes were utilized as discovery samples. PRSs derived from these GWASs were calculated for Japanese target subjects [718 PD patients and 1,717 healthy controls (HCs)]. The effects of these PRSs from European GWASs on the risk of PD in Japanese patients were investigated. The PRSs from European studies of anxiety disorders were marginally higher in Japanese PD patients than in HCs (p = 0.013). Regarding other psychiatric disorders, the PRSs for depression in European patients were significantly higher in Japanese PD patients than in HCs (p = 2.31×10

Identifiants

DOI: 10.1016/j.euroneuro.2020.11.003 PMID: 33189524
pubmed: 33189524
pii: S0924-977X(20)30936-6
doi: 10.1016/j.euroneuro.2020.11.003
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

87-96

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Conflict of Interest None.

Auteurs

Kazutaka Ohi (K)

Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan; Department of General Internal Medicine, Kanazawa Medical University, Ishikawa, Japan. Electronic address: k_ohi@gifu-u.ac.jp.

Takeshi Otowa (T)

Department of Neuropsychiatry, NTT Medical Center Tokyo, Tokyo, Japan.

Mihoko Shimada (M)

Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo Japan.

Shunsuke Sugiyama (S)

Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.

Yukimasa Muto (Y)

Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.

Shunsuke Tanahashi (S)

Graduate School of Medicine, Department of Psychiatry, Mie University, Mie, Japan.

Hisanobu Kaiya (H)

Panic Disorder Research Center, Warakukai Medical Corporation, Tokyo, Japan.

Fumichika Nishimura (F)

Center for Research on Counseling and Support Services, The University of Tokyo, Tokyo, Japan.

Tsukasa Sasaki (T)

Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.

Hisashi Tanii (H)

Center for Physical and Mental Health, Mie University, Mie, Japan; Graduate School of Medicine, Department of Health Promotion and Disease Prevention, Mie University, Mie, Japan.

Toshiki Shioiri (T)

Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Shared transethnic genetic basis of panic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Shared transethnic genetic basis of panic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Shared transethnic genetic basis of panic...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Shared transethnic genetic basis of panic...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble panique › Shared transethnic genetic basis of panic...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Shared transethnic genetic basis of panic...