Ivermectin: An Anthelmintic, an Insecticide, and Much More.
Animals
Anthelmintics
/ pharmacology
Antimalarials
/ pharmacology
Antineoplastic Agents
/ pharmacology
Antiviral Agents
/ pharmacology
Cell Line
Chloride Channels
/ drug effects
Dengue Virus
/ drug effects
Insecticides
/ pharmacology
Ion Channels
/ drug effects
Ivermectin
/ pharmacology
Nematoda
/ drug effects
SARS-CoV-2
/ drug effects
COVID-19 Drug Treatment
anthelmintic
anticancer
antimalaria
antivirus
insecticide
ivermectin
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
06
2020
revised:
13
10
2020
accepted:
14
10
2020
pubmed:
16
11
2020
medline:
30
12
2020
entrez:
15
11
2020
Statut:
ppublish
Résumé
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to reposition ivermectin for the treatment of other diseases that are not caused by helminth and insect parasites. The standard theory of its anthelmintic and insecticidal mode of action is that it is a selective positive allosteric modulator of glutamate-gated chloride channels found in nematodes and insects. At higher concentrations, ivermectin also acts as an allosteric modulator of ion channels found in host central nervous systems. In addition, in tissue culture, at concentrations higher than anthelmintic concentrations, ivermectin shows antiviral, antimalarial, antimetabolic, and anticancer effects. Caution is required before extrapolating from these preliminary repositioning experiments to clinical use, particularly for Covid-19 treatment, because of the high concentrations of ivermectin used in tissue-culture experiments.
Identifiants
pubmed: 33189582
pii: S1471-4922(20)30290-7
doi: 10.1016/j.pt.2020.10.005
pmc: PMC7853155
mid: NIHMS1646074
pii:
doi:
Substances chimiques
Anthelmintics
0
Antimalarials
0
Antineoplastic Agents
0
Antiviral Agents
0
Chloride Channels
0
Insecticides
0
Ion Channels
0
glutamate-gated chloride channels
0
Ivermectin
70288-86-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
48-64Subventions
Organisme : NIH HHS
ID : R01AI047194-17
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI138967
Pays : United States
Organisme : NIH HHS
ID : R21 AI13967
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI047194
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI155413
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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