The adiponectin agonist, AdipoRon, inhibits steroidogenesis and cell proliferation in human luteinized granulosa cells.
AMP-Activated Protein Kinases
/ metabolism
Adiponectin
/ agonists
Cell Cycle
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cells, Cultured
Enzyme Activation
/ drug effects
Female
Granulosa Cells
/ drug effects
Humans
Luteinization
/ drug effects
Mitochondria
/ drug effects
Models, Biological
PTEN Phosphohydrolase
/ metabolism
Peroxisome Proliferator-Activated Receptors
Piperidines
/ chemistry
Proto-Oncogene Proteins c-akt
/ metabolism
Steroids
/ biosynthesis
Adiponectin
Adiporon
Human luteinized granulosa cells
Steroid
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
09
08
2020
revised:
13
10
2020
accepted:
09
11
2020
pubmed:
16
11
2020
medline:
13
8
2021
entrez:
15
11
2020
Statut:
ppublish
Résumé
During obesity, excess body weight is not only associated with an increased risk of type 2-diabetes, but also several other pathological processes, such as infertility. Adipose tissue is the largest endocrine organ of the body that produces adipokines, including adiponectin. Adiponectin has been reported to control fertility through the hypothalamic-pituitary-gonadal axis, and folliculogenesis in the ovaries. In this study, we focused on a recent adiponectin-like synthetic agonist called AdipoRon, and its action in human luteinized granulosa cells. We demonstrated that AdipoRon activated the adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR) signalling pathways in human luteinized granulosa cells. A 25 μM AdipoRon stimulation reduced granulosa cell proliferation by inducing cell cycle arrest in G
Identifiants
pubmed: 33189865
pii: S0303-7207(20)30382-8
doi: 10.1016/j.mce.2020.111080
pii:
doi:
Substances chimiques
AdipoRon
0
Adiponectin
0
Peroxisome Proliferator-Activated Receptors
0
Piperidines
0
Steroids
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
PTEN Phosphohydrolase
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111080Informations de copyright
Copyright © 2020. Published by Elsevier B.V.