Innovations in Geroscience to enhance mobility in older adults.
Age
Healthspan
Longevity
Mobility
Obesity
Sarcopenia
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
17
07
2020
revised:
15
10
2020
accepted:
16
10
2020
pubmed:
17
11
2020
medline:
16
12
2020
entrez:
16
11
2020
Statut:
ppublish
Résumé
Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of geroscience is to increase healthspan, which refers to extending the portion of the lifespan in which the individual experiences enjoyment, satisfaction, and wellness. An important facet of this goal is preserving mobility, defined as the ability to move independently. Despite this clear purpose, this has proven to be a challenging endeavor as mobility and function in later life are influenced by a complex interaction of factors across multiple domains. Moreover, findings over the past decade have highlighted the complexity of walking and how targeting multiple systems, including the brain and sensory organs, as well as the environment in which a person lives, can have a dramatic effect on an older person's mobility and function. For these reasons, behavioral interventions that incorporate complex walking tasks and other activities of daily living appear to be especially helpful for improving mobility function. Other pharmaceutical interventions, such as oxytocin, and complementary and alternative interventions, such as massage therapy, may enhance physical function both through direct effects on biological mechanisms related to mobility, as well as indirectly through modulation of cognitive and socioemotional processes. Thus, the purpose of the present review is to describe evolving interventional approaches to enhance mobility and maintain healthspan in the growing population of older adults in the United States and countries throughout the world. Such interventions are likely to be greatly assisted by technological advances and the widespread adoption of virtual communications during and after the COVID-19 era.
Identifiants
pubmed: 33191210
pii: S0531-5565(20)30471-X
doi: 10.1016/j.exger.2020.111123
pmc: PMC7581361
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111123Subventions
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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