Plasmodium sporozoites on the move: Switching from cell traversal to productive invasion of hepatocytes.
Plasmodium sporozoites
apical organelles
cell traversal
host cell invasion
malaria
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
10
11
2020
received:
14
09
2020
accepted:
11
11
2020
pubmed:
17
11
2020
medline:
1
12
2021
entrez:
16
11
2020
Statut:
ppublish
Résumé
Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites migrate through the dermis, enter the bloodstream, and rapidly traffic to the liver. They cross the liver sinusoidal barrier and traverse several hepatocytes before switching to productive invasion of a final one for replication inside a parasitophorous vacuole. Cell traversal and productive invasion are functionally independent processes that require proteins secreted from specialized secretory organelles known as micronemes. In this review, we summarize the current understanding of how sporozoites traverse through cells and productively invade hepatocytes, and discuss the role of environmental sensing in switching from a migratory to an invasive state. We propose that timely controlled secretion of distinct microneme subsets could play a key role in successful migration and infection of hepatocytes. A better understanding of these essential biological features of the Plasmodium sporozoite may contribute to the development of new strategies to fight against the very first and asymptomatic stage of malaria.
Identifiants
pubmed: 33191548
doi: 10.1111/mmi.14645
pmc: PMC8247013
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
870-881Informations de copyright
© 2020 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.
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