Effects of Aerobic Exercise, Cognitive and Combined Training on Cognition in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial.
aging
computerized cognitive training
lifestyle interventions
neuropsychology
physical activity (exercise)
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
07
2020
accepted:
07
10
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Lifestyle interventions are promising strategies to promote cognitive health in aging. Projecte Moviment examines if aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB) improves cognition, psychological health, and physical status compared to a control group. We assessed the moderating role of age and sex and the mediating effects of cardiorespiratory fitness (CRF), physical activity (PA), and psychological health on intervention-related cognitive benefits. This was a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial (RCT). 96 healthy adults aged 50-70 years were assigned to AE, CCT, COMB, and a wait-list control group. The per protocol sample, which completed the intervention with a level of adherence > 80%, consisted of 82 participants (62% female; age = 58.38 ± 5.47). We assessed cognition, psychological health, CRF, and energy expenditure in PA at baseline and after the intervention. We regressed change in each outcome on the treatment variables, baseline score, sex, age, and education. We used PROCESS Macro to perform the mediation and moderation analyses. AE benefited Working Memory (SMD = 0.29, A 12-week AE program improved Executive Function and Attention-Speed in healthy late-middle-aged adults. Combining it with CCT did not provide further benefits. Our results add support to the clinical relevance of even short-term AE as an intervention to enhance cognition and highlight the mediating role of change in S-PA in these benefits. www.ClinicalTrials.gov, identifier NCT03123900.
Sections du résumé
BACKGROUND
BACKGROUND
Lifestyle interventions are promising strategies to promote cognitive health in aging. Projecte Moviment examines if aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB) improves cognition, psychological health, and physical status compared to a control group. We assessed the moderating role of age and sex and the mediating effects of cardiorespiratory fitness (CRF), physical activity (PA), and psychological health on intervention-related cognitive benefits.
METHODS
METHODS
This was a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial (RCT). 96 healthy adults aged 50-70 years were assigned to AE, CCT, COMB, and a wait-list control group. The per protocol sample, which completed the intervention with a level of adherence > 80%, consisted of 82 participants (62% female; age = 58.38 ± 5.47). We assessed cognition, psychological health, CRF, and energy expenditure in PA at baseline and after the intervention. We regressed change in each outcome on the treatment variables, baseline score, sex, age, and education. We used PROCESS Macro to perform the mediation and moderation analyses.
RESULTS
RESULTS
AE benefited Working Memory (SMD = 0.29,
CONCLUSION
CONCLUSIONS
A 12-week AE program improved Executive Function and Attention-Speed in healthy late-middle-aged adults. Combining it with CCT did not provide further benefits. Our results add support to the clinical relevance of even short-term AE as an intervention to enhance cognition and highlight the mediating role of change in S-PA in these benefits.
CLINICAL TRIAL REGISTRATION
BACKGROUND
www.ClinicalTrials.gov, identifier NCT03123900.
Identifiants
pubmed: 33192485
doi: 10.3389/fnagi.2020.590168
pmc: PMC7664521
doi:
Banques de données
ClinicalTrials.gov
['NCT03123900']
Types de publication
Journal Article
Langues
eng
Pagination
590168Informations de copyright
Copyright © 2020 Roig-Coll, Castells-Sánchez, Lamonja-Vicente, Torán-Monserrat, Pera, García-Molina, Tormos, Montero-Alía, Alzamora, Dacosta-Aguayo, Soriano-Raya, Cáceres, Erickson and Mataró.
Références
Eur J Ageing. 2006 Nov 10;3(4):179
pubmed: 28794762
Brain Plast. 2018 Dec 12;4(1):53-63
pubmed: 30564546
PLoS Med. 2014 Nov 18;11(11):e1001756
pubmed: 25405755
Brain Behav Immun. 2012 Jul;26(5):811-9
pubmed: 22172477
Med Sci Sports Exerc. 1982;14(5):377-81
pubmed: 7154893
Am J Prev Med. 2012 Feb;42(2):109-19
pubmed: 22261206
Am J Health Behav. 2015 Jan;39(1):62-7
pubmed: 25290598
Br J Sports Med. 2018 Feb;52(3):154-160
pubmed: 28438770
Mayo Clin Proc. 2016 Jun;91(6):755-62
pubmed: 27161032
Stroke. 2015 Apr;46(4):1059-64
pubmed: 25700290
Arch Neurobiol (Madr). 1992 Nov-Dec;55(6):262-6
pubmed: 1492780
Syst Rev. 2017 Dec 19;6(1):259
pubmed: 29258596
Front Aging Neurosci. 2015 Mar 09;7:14
pubmed: 25805989
BMC Public Health. 2016 Jan 22;16:62
pubmed: 26801097
Psychosom Med. 2010 Apr;72(3):239-52
pubmed: 20223924
Rev Esp Salud Publica. 2012 Oct;86(5):495-508
pubmed: 23223762
Front Neuroendocrinol. 2017 Jul;46:71-85
pubmed: 28442274
Front Aging Neurosci. 2019 Aug 14;11:216
pubmed: 31481889
Front Hum Neurosci. 2016 Dec 08;10:626
pubmed: 28018195
PLoS One. 2015 Jun 22;10(6):e0130831
pubmed: 26098943
PLoS One. 2017 May 1;12(5):e0176742
pubmed: 28459873
BMC Med Inform Decis Mak. 2014 Jul 19;14:58
pubmed: 25038823
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2012;19(1-2):248-63
pubmed: 22313174
Neuropsychiatr Dis Treat. 2016 Jun 21;12:1457-66
pubmed: 27382288
BMC Geriatr. 2011 May 26;11:27
pubmed: 21615936
Psychol Bull. 2019 Jul;145(7):698-733
pubmed: 30998045
J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):755-763
pubmed: 31054254
J Aging Phys Act. 2015 Jan;23(1):72-7
pubmed: 24413071
Cochrane Database Syst Rev. 2015 Apr 22;(4):CD005381
pubmed: 25900537
J Gerontol B Psychol Sci Soc Sci. 2006 Sep;61(5):S281-7
pubmed: 16960242
Psychol Sci. 2003 Mar;14(2):125-30
pubmed: 12661673
Int J Sports Med. 2002 Aug;23(6):415-21
pubmed: 12215960
Med Sci Sports Exerc. 1987 Jun;19(3):253-9
pubmed: 3600239
Nurs Open. 2019 Mar 19;6(3):849-859
pubmed: 31367408
Clin Interv Aging. 2017 May 25;12:903-910
pubmed: 28579767
Neuroimage. 2016 Jan 15;125:291-300
pubmed: 26439424
PLoS One. 2019 Jan 7;14(1):e0210292
pubmed: 30615666
Semin Hear. 2015 Aug;36(3):111-21
pubmed: 27516712
Arch Clin Neuropsychol. 2004 Mar;19(2):203-14
pubmed: 15010086
Arch Clin Neuropsychol. 2009 Jun;24(4):395-411
pubmed: 19648583
Neurol Clin Pract. 2018 Jun;8(3):257-265
pubmed: 30105166
Am J Prev Med. 2005 Apr;28(3):298-304
pubmed: 15766620
IEEE J Biomed Health Inform. 2015 Jan;19(1):124-31
pubmed: 25204001
Neurosci Biobehav Rev. 2014 Jul;44:206-20
pubmed: 24705268
BMC Geriatr. 2016 Jul 18;16:141
pubmed: 27431673
JAMA. 2002 Nov 13;288(18):2271-81
pubmed: 12425704
Neuropsychologia. 2001;39(11):1150-7
pubmed: 11527552
J Gerontol B Psychol Sci Soc Sci. 2019 May 23;:
pubmed: 31121030
Brain Res Rev. 2006 Aug 30;52(1):119-30
pubmed: 16490256