Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era.
cancer genes
cancer predisposition
cancer syndromes
hereditary neoplastic syndromes
medulloblastoma
pediatric brain tumors
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
05
2020
accepted:
30
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
Identifiants
pubmed: 33194646
doi: 10.3389/fonc.2020.566822
pmc: PMC7658916
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
566822Informations de copyright
Copyright © 2020 Carta, Del Baldo, Miele, Po, Besharat, Nazio, Colafati, Piccirilli, Agolini, Rinelli, Lodi, Cacchione, Carai, Boccuto, Ferretti, Locatelli and Mastronuzzi.
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