Deciphering Cancer Cell Behavior From Motility and Shape Features: Peer Prediction and Dynamic Selection to Support Cancer Diagnosis and Therapy.
cancer heterogeneity
cell motility
drug screening
dynamic feature selection
machine learning
metastatic cancer cell detection
peer prediction
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
07
2020
accepted:
08
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Cell motility varies according to intrinsic features and microenvironmental stimuli, being a signature of underlying biological phenomena. The heterogeneity in cell response, due to multilevel cell diversity especially relevant in cancer, poses a challenge in identifying the biological scenario from cell trajectories. We propose here a novel peer prediction strategy among cell trajectories, deciphering cell state (tumor vs. nontumor), tumor stage, and response to the anticancer drug etoposide, based on morphology and motility features, solving the strong heterogeneity of individual cell properties. The proposed approach first barcodes cell trajectories, then automatically selects the good ones for optimal model construction (good teacher and test sample selection), and finally extracts a collective response from the heterogeneous populations
Identifiants
pubmed: 33194709
doi: 10.3389/fonc.2020.580698
pmc: PMC7606946
doi:
Types de publication
Journal Article
Langues
eng
Pagination
580698Informations de copyright
Copyright © 2020 D'Orazio, Corsi, Mencattini, Di Giuseppe, Colomba Comes, Casti, Filippi, Di Natale, Ghibelli and Martinelli.
Références
Science. 2015 Nov 20;350(6263):972-8
pubmed: 26516201
Sensors (Basel). 2019 Sep 20;19(19):
pubmed: 31547154
IEEE Trans Med Imaging. 2020 Jan;39(1):1-10
pubmed: 31135355
Front Oncol. 2015 Feb 26;5:45
pubmed: 25767773
Nat Rev Mol Cell Biol. 2009 Jul;10(7):445-57
pubmed: 19546857
Sci Rep. 2017 Oct 6;7(1):12737
pubmed: 28986543
Cell Syst. 2017 Jun 28;4(6):600-610.e6
pubmed: 28601558
IEEE Trans Biomed Eng. 2019 Oct;66(10):2882-2888
pubmed: 30735982
Sensors (Basel). 2020 Mar 10;20(5):
pubmed: 32164292
Cell Rep. 2018 Dec 26;25(13):3884-3893.e3
pubmed: 30590056
IEEE Trans Image Process. 2001;10(2):266-77
pubmed: 18249617
Sci Rep. 2019 May 1;9(1):6789
pubmed: 31043687
Radiology. 1982 Apr;143(1):29-36
pubmed: 7063747
J Struct Biol. 2005 Aug;151(2):182-95
pubmed: 16043363
Haematologica. 2015 Jan;100(1):e4-6
pubmed: 25261094
J Craniofac Surg. 2016 Jan;27(1):222-8
pubmed: 26703050