Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor.
ERα
ERβ
ESR1
ESR2
breast cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
07
2020
accepted:
15
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. ERβ has multiple isoforms that show differing association with prognosis. Expression levels of the full length ERβ1 isoform are often lower in aggressive cancers as compared to normal tissue. High ERβ1 expression is associated with improved overall survival in women with breast cancer. The promise of ERβ activation, as a potential targeted therapy, is based on concurrent activation of multiple tumor suppressor pathways with few side effects compared to chemotherapy. Thus, ERβ is a nuclear receptor with broad-spectrum tumor suppressor activity, which could serve as a potential treatment target in a variety of human cancers including breast cancer. Further development of highly selective agonists that lack ERα agonist activity, will be necessary to fully harness the potential of ERβ.
Identifiants
pubmed: 33194742
doi: 10.3389/fonc.2020.587386
pmc: PMC7645238
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
587386Subventions
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Informations de copyright
Copyright © 2020 Mal, Magner, David, Datta, Vallabhaneni, Kassem, Manouchehri, Willingham, Stover, Vandeusen, Sardesai, Williams, Wesolowski, Lustberg, Ganju, Ramaswamy and Cherian.
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