Hypertensive Crisis in Pediatric Patients: An Overview.

acute severe hypertension hypertensive crisis hypertensive emergency hypertensive urgency management

Journal

Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492

Informations de publication

Date de publication:
2020
Historique:
received: 29 07 2020
accepted: 08 09 2020
entrez: 16 11 2020
pubmed: 17 11 2020
medline: 17 11 2020
Statut: epublish

Résumé

Hypertensive crisis can be a source of morbidity and mortality in the pediatric population. While the epidemiology has been difficult to pinpoint, it is well-known that secondary causes of pediatric hypertension contribute to a greater incidence of hypertensive crisis in pediatrics. Hypertensive crisis may manifest with non-specific symptoms as well as distinct and acute symptoms in the presence of end-organ damage. Hypertensive emergency, the form of hypertensive crisis with end-organ damage, may present with more severe symptoms and lead to permanent organ damage. Thus, it is crucial to evaluate any pediatric patient suspected of hypertensive emergency with a thorough workup while acutely treating the elevated blood pressure in a gradual manner. Management of hypertensive crisis is chosen based on the presence of end-organ damage and can range from fast-acting intravenous medication to oral medication for less severe cases. Treatment of such demands a careful balance between decreasing blood pressure in a gradual manner while preventing damage end-organ damage. In special situations, protocols have been established for treatment of hypertensive crisis, such as in the presence of endocrinologic neoplasms, monogenic causes of hypertension, renal diseases, and cardiac disease. With the advent of telehealth, clinicians are further able to extend their reach of care to emergency settings and aid emergency medical service (EMS) providers in real time. In addition, further updates on the evolving topic of hypertension in the pediatric population and novel drug development continues to improve outcomes and efficiency in diagnosis and management of hypertension and consequent hypertensive crisis.

Identifiants

pubmed: 33194923
doi: 10.3389/fped.2020.588911
pmc: PMC7606848
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

588911

Informations de copyright

Copyright © 2020 Raina, Mahajan, Sharma, Chakraborty, Mahajan, Sethi, Kapur and Kaelber.

Références

J Thorac Cardiovasc Surg. 2008 Aug;136(2):321-8
pubmed: 18692637
Ophthalmology. 2005 Feb;112(2):e7-e11
pubmed: 15691546
Circulation. 2004 Oct 12;110(15):2241-5
pubmed: 15466625
Drug Saf. 1998 Aug;19(2):99-122
pubmed: 9704248
Arq Bras Endocrinol Metabol. 2004 Oct;48(5):687-96
pubmed: 15761540
Korean J Pediatr. 2017 Aug;60(8):266-271
pubmed: 29042869
BMC Cardiovasc Disord. 2017 Feb 8;17(1):55
pubmed: 28178928
Eur J Pediatr. 2012 Oct;171(10):1433-9
pubmed: 21404100
JAMA. 2002 Mar 20;287(11):1427-34
pubmed: 11903030
Circulation. 2019 Jul 9;140(2):138-146
pubmed: 31014072
Am Fam Physician. 2010 Dec 15;82(12):1471-8
pubmed: 21166367
J Cardiovasc Pharmacol. 1980;2 Suppl 2:S217-27
pubmed: 6156358
Pediatr Cardiol. 2007 Jan-Feb;28(1):27-33
pubmed: 17308944
Prog Pediatr Cardiol. 2001 Jan;12(2):177-188
pubmed: 11223345
Clin Ther. 2003 Jan;25(1):1-18
pubmed: 12637109
J Child Neurol. 1999 May;14(5):277-81
pubmed: 10342593
Lancet. 1987 Oct 10;2(8563):821-4
pubmed: 2889032
Arch Dis Child. 2010 Oct;95(10):832-6
pubmed: 20656727
Int J Mol Sci. 2017 May 26;18(6):
pubmed: 28587112
JAMA Pediatr. 2019 Oct 7;:1-10
pubmed: 31589252
J Thorac Cardiovasc Surg. 1998 Apr;115(4):890-7
pubmed: 9576226
Handb Clin Neurol. 2015;132:29-73
pubmed: 26564070
Int J Nephrol. 2012;2012:420247
pubmed: 22577545
Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
pubmed: 15286277
J Am Geriatr Soc. 1996 Jan;44(1):50-3
pubmed: 8537590
World J Clin Cases. 2015 Jun 16;3(6):510-3
pubmed: 26090371
Circulation. 2012 Apr 3;125(13):1594-6
pubmed: 22379111
Pediatr Clin North Am. 2006 Jun;53(3):493-512, viii
pubmed: 16716793
Drug Alcohol Depend. 2019 Jul 1;200:161-167
pubmed: 31146203
J Intensive Care Med. 2010 Nov-Dec;25(6):349-52
pubmed: 20837631
Am J Med. 1990 Apr;88(4):325-31
pubmed: 2327419
Clin Sci (Lond). 1981 Apr;60(4):343-8
pubmed: 6265136
Pediatr Emerg Care. 2005 May;21(5):322-4
pubmed: 15874816
Arch Dis Child. 2012 Mar;97(3):200-5
pubmed: 22241908
J Pediatr. 1977 May;90(5):813-9
pubmed: 323442
Pediatr Emerg Care. 2005 Jun;21(6):391-6; quiz 397
pubmed: 15942520
J Neonatal Perinatal Med. 2013;6(3):267-72
pubmed: 24246601
Curr Hypertens Rep. 2019 Apr 4;21(4):31
pubmed: 30949771
Pediatr Nephrol. 2002 Sep;17(9):748-53
pubmed: 12215829
Pediatrics. 2017 Sep;140(3):
pubmed: 28827377
Hypertens Res. 2011 Sep;34(9):1004-10
pubmed: 21654756
Am J Surg. 2007 Dec;194(6):792-6; discussion 796-7
pubmed: 18005773
JAMA. 2007 Aug 22;298(8):874-9
pubmed: 17712071
Horm Metab Res. 2012 Nov;44(12):867-78
pubmed: 22932914
Cardiol Rev. 2009 Jul-Aug;17(4):159-64
pubmed: 19525677
Curr Hypertens Rep. 2009 Oct;11(5):315-22
pubmed: 19737447
Crit Care Nurs Clin North Am. 2015 Dec;27(4):439-47
pubmed: 26567490
Arch Dis Child. 1967 Feb;42(221):34-9
pubmed: 6019466
J Forensic Sci. 2009 Nov;54(6):1485-7
pubmed: 19878416
Clin Endocrinol (Oxf). 1999 Jul;51(1):67-71
pubmed: 10468967
Blood Press. 2018 Dec;27(6):314-340
pubmed: 30380928
Pituitary. 2002;5(2):77-82
pubmed: 12675504
J Clin Endocrinol Metab. 2008 Sep;93(9):3266-81
pubmed: 18552288
Acta Radiol. 2006 Oct;47(8):764-74
pubmed: 17050355
Pediatr Radiol. 2014 Jan;44(1):42-9
pubmed: 24037085
Clin Cancer Res. 2009 Oct 15;15(20):6378-85
pubmed: 19825962
Am J Public Health. 1992 Dec;82(12):1607-12
pubmed: 1456334
Acad Emerg Med. 2002 Jan;9(1):27-34
pubmed: 11772666
Pediatr Nephrol. 2009 Oct;24(10):1929-37
pubmed: 17647025
Interact Cardiovasc Thorac Surg. 2003 Jun;2(2):111-5
pubmed: 17670004
Ren Fail. 2007;29(3):295-302
pubmed: 17497443
N Engl J Med. 2007 Feb 8;356(6):601-10
pubmed: 17287480
Pediatr Nephrol. 2012 May;27(5):741-51
pubmed: 21773822
Pediatr Crit Care Med. 2011 Jan;12(1):28-32
pubmed: 20495503
Nephron Physiol. 2003 Jan;93(1):P3-13
pubmed: 12411725
Circulation. 2007 Sep 25;116(13):1488-96
pubmed: 17846287
J Clin Endocrinol Metab. 2000 Sep;85(9):3313-8
pubmed: 10999827
JAMA. 2003 May 21;289(19):2560-72
pubmed: 12748199
Pediatr Radiol. 2008 May;38 Suppl 2:S259-66
pubmed: 18401623
Clin Hypertens. 2016 Apr 18;22:10
pubmed: 27092268
J Clin Hypertens (Greenwich). 2010 Nov;12(11):850-5
pubmed: 21054771
Lancet. 1966 Jul 16;2(7455):117-21
pubmed: 4161375
J Clin Endocrinol Metab. 2012 Nov;97(11):E2125-32
pubmed: 22948763
J Pediatr Ophthalmol Strabismus. 2013 Jul-Aug;50(4):222-8
pubmed: 23521027
Am J Hypertens. 2015 Jan;28(1):73-80
pubmed: 24842390
Medicine (Baltimore). 1991 Jan;70(1):46-66
pubmed: 1988766
J Hypertens. 2016 Oct;34(10):1887-920
pubmed: 27467768
BMJ. 1997 Mar 29;314(7085):936-40
pubmed: 9099117
N Engl J Med. 1992 Sep 10;327(11):776-81
pubmed: 1501654
Hypertens Res. 2011 Jun;34(6):665-73
pubmed: 21512515
J Child Neurol. 1995 May;10(3):236-9
pubmed: 7642896
Glob Cardiol Sci Pract. 2015 Nov 18;2015(4):44
pubmed: 26779519
Pediatr Nephrol. 1999 Aug;13(6):493-500
pubmed: 10452277
Pediatr Nephrol. 2009 May;24(5):943-50
pubmed: 18566838
J Pediatr. 2001 Jul;139(1):34-7
pubmed: 11445791
J Clin Hypertens (Greenwich). 2007 May;9(5):399-405
pubmed: 17485976
J Korean Med Sci. 2010 Sep;25(9):1379-83
pubmed: 20808686
Arch Dis Child. 1992 Sep;67(9):1089-92
pubmed: 1417052
Card Fail Rev. 2015 Oct;1(2):69-74
pubmed: 28785435
Arch Ophthalmol. 1994 Jan;112(1):92-8
pubmed: 8285901
Can J Cardiol. 2018 May;34(5):506-525
pubmed: 29731013
J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42
pubmed: 24893135
Fam Pract. 2004 Aug;21(4):420-4
pubmed: 15249531
Am J Hypertens. 2008 Feb;21(2):159-65
pubmed: 18188162
Chest. 1983 Feb;83(2 Suppl):357-9
pubmed: 6337026
Indian J Pediatr. 2011 May;78(5):569-75
pubmed: 21271305
Pediatr Neonatol. 2010 Feb;51(1):44-51
pubmed: 20225538
Clin Endocrinol (Oxf). 2007 May;66(5):607-18
pubmed: 17492946
Pediatr Nephrol. 2012 Jun;27(6):1037-40
pubmed: 22366877
Pediatr Nephrol. 1998 Jan;12(1):40-2
pubmed: 9502566
Indian Pediatr. 2000 Mar;37(3):268-74
pubmed: 10750068
J Hypertens. 2019 Feb;37(2):297-306
pubmed: 30044314
J Clin Hypertens (Greenwich). 2017 Jul;19(7):704-712
pubmed: 28560799
J Hypertens. 2015 Dec;33(12):2500-11
pubmed: 26372319
J Cardiovasc Pharmacol. 1990;15 Suppl 1:S84-6
pubmed: 1695311
J Pediatr. 1976 Aug;89(2):306-9
pubmed: 940030
Arch Pediatr Adolesc Med. 1996 Feb;150(2):169-74
pubmed: 8556121
Pediatr Nephrol. 2009 Jun;24(6):1101-12
pubmed: 18839219
Interv Neurol. 2014 May;2(3):118-22
pubmed: 25187787
Indian J Endocrinol Metab. 2012 Sep;16(5):728-39
pubmed: 23087856
Paediatr Drugs. 2006;8(6):357-73
pubmed: 17154643
Pediatr Nephrol. 2008 Mar;23(3):363-71
pubmed: 17990006
J Pediatr. 1990 Oct;117(4):664-7
pubmed: 2170612
Kidney Int. 2001 Jul;60(1):381-90
pubmed: 11422778
Hypertension. 2005 Jan;45(1):142-61
pubmed: 15611362
Clin Hypertens. 2016 May 17;22:15
pubmed: 27190633
Tech Vasc Interv Radiol. 2010 Dec;13(4):238-43
pubmed: 21055678
Curr Opin Pediatr. 2007 Apr;19(2):192-8
pubmed: 17496764
BMC Anesthesiol. 2008 Oct 06;8:6
pubmed: 18837982
J Clin Hypertens (Greenwich). 2017 May;19(5):524-529
pubmed: 27896928
Can J Cardiol. 2020 May;36(5):596-624
pubmed: 32389335

Auteurs

Rupesh Raina (R)

Department of Nephrology, Akron Children's Hospital, Akron, OH, United States.
Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, United States.

Zubin Mahajan (Z)

Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, United States.

Aditya Sharma (A)

Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.

Ronith Chakraborty (R)

Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, United States.

Sarisha Mahajan (S)

Cleveland Clinic Akron General Medical Center, Akron, OH, United States.

Sidharth K Sethi (SK)

Pediatric Nephrology and Pediatric Kidney Transplantation, The Medicity Hospital, Kidney and Urology Institute, Medanta, Gurgaon, India.

Gaurav Kapur (G)

Division of Pediatric Nephrology and Hypertension, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, United States.

David Kaelber (D)

Departments of Pediatrics, Internal Medicine, Population and Quantitative Health Sciences, Center for Clinical Informatics Research and Education, Case Western Reserve University and Metro Health System, Cleveland, OH, United States.

Classifications MeSH