Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation.
Brugada syndrome
SCN5A mutation
depolarization
disease modeling
induced pluripotent stem cells
repolarization
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
08
2020
accepted:
01
10
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young people, while the underlying mechanisms are not completely understood. Here, we investigated the pathophysiological phenotypes and mechanisms using induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) from two BrS patients (BrS-CMs) carrying a heterozygous
Identifiants
pubmed: 33195263
doi: 10.3389/fcell.2020.592893
pmc: PMC7642519
doi:
Types de publication
Journal Article
Langues
eng
Pagination
592893Informations de copyright
Copyright © 2020 Li, Stauske, Luo, Wagner, Vollrath, Mehnert, Schubert, Cyganek, Chen, Hasheminasab, Wulf, El-Armouche, Maier, Hasenfuss and Guan.
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