A Middle-Out Modeling Strategy to Extend a Colon Cancer Logical Model Improves Drug Synergy Predictions in Epithelial-Derived Cancer Cell Lines.
cancer cell fate decisions
drug synergy prediction
logical model simulations
middle-out modeling
model curation
model validation
systems medicine
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
10
2019
accepted:
22
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
17
11
2020
Statut:
epublish
Résumé
Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and phenotypic tumor profiles and variation in drug treatment response.
Identifiants
pubmed: 33195403
doi: 10.3389/fmolb.2020.502573
pmc: PMC7581946
doi:
Types de publication
Journal Article
Langues
eng
Pagination
502573Informations de copyright
Copyright © 2020 Tsirvouli, Touré, Niederdorfer, Vázquez, Flobak and Kuiper.
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