Influence of insulin on the healing of exposed dental pulp after pulp capping: An experimental study in a dog model.
blood glucose
dental pulp
dentine bridge
diabetes mellitus
hyperglycemia
Journal
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
ISSN: 1754-4505
Titre abrégé: Spec Care Dentist
Pays: United States
ID NLM: 8103755
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
05
2020
revised:
07
08
2020
accepted:
30
10
2020
pubmed:
17
11
2020
medline:
15
1
2021
entrez:
16
11
2020
Statut:
ppublish
Résumé
This study investigates the influence of insulin on pulp tissue healing after pulp capping in diabetic dogs. Diabetes mellitus was induced in four dogs, and their blood glucose levels were adjusted by insulin to normoglycemic level in two dogs (normoglycemic group) and to hyperglycemic level in two dogs (hyperglycemic group). Class V buccal cavities were performed in 15 teeth in each diabetic dog and two normal dogs (control group). The three groups (30 teeth each) were divided according to the capping materials into three subgroups (10 teeth each) including: subgroup A - mineral trioxide aggregate (MTA), subgroup B - bioaggregate (BA), and subgroup C - calcium hydroxide (Ca(OH) The hyperglycemic diabetic group exhibited significant higher inflammatory cell count and scores and lower dentine bridge thickness than those of the normoglycemic diabetic and control groups (P < .05). There were no significant differences in these parameters between the normoglycemic diabetic and control groups (P > .05). Insulin has favourable effects on the pulp tissue healing after pulp capping in diabetic dogs.
Sections du résumé
BACKGROUND
BACKGROUND
This study investigates the influence of insulin on pulp tissue healing after pulp capping in diabetic dogs.
METHODS
METHODS
Diabetes mellitus was induced in four dogs, and their blood glucose levels were adjusted by insulin to normoglycemic level in two dogs (normoglycemic group) and to hyperglycemic level in two dogs (hyperglycemic group). Class V buccal cavities were performed in 15 teeth in each diabetic dog and two normal dogs (control group). The three groups (30 teeth each) were divided according to the capping materials into three subgroups (10 teeth each) including: subgroup A - mineral trioxide aggregate (MTA), subgroup B - bioaggregate (BA), and subgroup C - calcium hydroxide (Ca(OH)
RESULTS
RESULTS
The hyperglycemic diabetic group exhibited significant higher inflammatory cell count and scores and lower dentine bridge thickness than those of the normoglycemic diabetic and control groups (P < .05). There were no significant differences in these parameters between the normoglycemic diabetic and control groups (P > .05).
CONCLUSION
CONCLUSIONS
Insulin has favourable effects on the pulp tissue healing after pulp capping in diabetic dogs.
Substances chimiques
Aluminum Compounds
0
Calcium Compounds
0
Drug Combinations
0
Insulin
0
Oxides
0
Silicates
0
Calcium Hydroxide
PF5DZW74VN
Types de publication
Journal Article
Langues
eng
Pagination
49-59Informations de copyright
© 2020 Special Care Dentistry Association and Wiley Periodicals LLC.
Références
Scarano A, Manzon L, Di Giorgio R, Orsini G, Tripodi D, Piattelli A. Direct capping with four different materials in humans: histological analysis of odontoblast activity. J Endod. 2003;29(11):729-734.
Al-Sherbiny IM, Farid MH, Abu-Seida AM, Motawea IT, Bastawy HA. Chemico-physical and mechanical evaluation of three calcium silicate-based pulp capping materials. Saudi Dent J. 2020. https://doi.org/10.1016/j.sdentj.2020.02.001.
El Ashry SH, Abu-Seida AM, Emara RA. Influence of addition of osteogenic supplements to mineral trioxide aggregate on the gene expression level of odontoblastic markers following pulp capping in dogs. Vet Arhiv. 2016;86:685-897.
Negm AM, Hassanien EE, Abu-Seida AM, Nagy MM. Biological evaluation of a new pulp capping material developed from Portland cement. Exp Toxicol Pathol. 2017;69:115-122.
Negm AM, Hassanien EE, Abu-Seida AM, Nagy MM. Physical evaluation of a new pulp capping material developed from Portland cement. J Clin Exp Dent. 2016;8:278-283.
Saleh RS, Nagi SM, Khallaf ME, et al. In-vivo assessment of dentin bridge formation after using MTA and experimental propolis paste as direct pulp capping material. Res J Pharm Biol Chem Sci. 2016;7:1244-1250.
Abo El-Mal EO, Abu-Seida AM, El Ashry SH. A comparative study of the physicochemical properties of hesperidin, MTA-Angelus and calcium hydroxide as pulp capping materials (2019). Saudi Dent J. 2019;31:219-227.
Al-Sherbiny IM, Abu-Seida AM, Farid MH, Motawea IT, Bastawy HA. Histopathological pulp response of dog's teeth capped with biosealer and biodentine: an in vivo study. Saudi Endod J. 2020;10(3):226-233.
Chung C-R, Kim E, Shin S-J. Biocompatibility of bioaggregate cement on human pulp and periodontal ligament (PDL) derived cells. J Korean Acad Conserv Dent. 2010;35(6):473-478.
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of Diabetes Mellitus. Diabetes Care. 1997;20: 1183-1197.
Fouad AF. Diabetes mellitus as a modulating factor of endodontic infections. J Dent Educ. 2003;67(4):459-467.
Accorinte Mde L, Holland R, Reis A, et al. Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod. 2008;34(1):1-6.
Lima SM, Grisi DC, Kogawa EM, et al. Diabetes mellitus and inflammatory pulpal and periapical disease: a review. Int Endod J. 2013;46(8):700-709.
El Ashry S, Abu-Seida AM, Al-Boghdady H, Abdel-Fattah M. The effect of different formulations of calcium hydroxide on healing of intentionally induced periapical lesions in dogs. Pak Vet J. 2013;3:48-52.
Park JW, Hong SH, Kim JH, Lee SJ, Shin SJ. X-ray diffraction analysis of white ProRoot MTA and Diadent BioAggregate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(1):155-158.
Alazrag MA, AbuSeida AM, ElBatouty KM. El Ashry SH. Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTAangelus and biodentine as a furcation perforation repair material. BMC Oral Health. 2020;20:298.
Tziafas D, Kolokuris I, Alvanou A, Kaidoglou K. Short-term dentinogenic response of dog dental pulp tissue after its induction by demineralized or native dentine, or predentine. Arch Oral Biol. 1992;37(2):119-128.
Guo B, Xie S, Que K, et al. Altered circadian rhythm of pulp sensibility in elderly diabetic and hypertensive patients. Chin Med J (Engl). 2007;120(11):1024-1026.
Bender IB, Bender AB. Diabetes mellitus and the dental pulp. J Endod. 2003;29(6):383-389.
Nair PN, Duncan HF, Pitt Ford TR, Luder HU. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. Int Endod J. 2008;41(2):128-150.