Long-term low-level ambient air pollution exposure and risk of lung cancer - A pooled analysis of 7 European cohorts.

Air Pollutants / analysis Air Pollution / adverse effects Environmental Exposure / analysis Europe / epidemiology Humans Lung Neoplasms / chemically induced Particulate Matter / analysis
Air pollution Dose response relationship Lung cancer incidence Particulate matter

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
01 2021
Historique:
received: 18 06 2020
revised: 15 09 2020
accepted: 26 10 2020
pubmed: 17 11 2020
medline: 24 4 2021
entrez: 16 11 2020
Statut: ppublish

Résumé

Ambient air pollution has been associated with lung cancer, but the shape of the exposure-response function - especially at low exposure levels - is not well described. The aim of this study was to address the relationship between long-term low-level air pollution exposure and lung cancer incidence. The "Effects of Low-level Air Pollution: a Study in Europe" (ELAPSE) collaboration pools seven cohorts from across Europe. We developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates for nitrogen dioxide (NO The analyses included 307,550 cohort participants. During a mean follow-up of 18.1 years, 3956 incident lung cancer cases occurred. Median (Q1, Q3) annual (2010) exposure levels of NO Long-term ambient PM

Sections du résumé

BACKGROUND/AIM
Ambient air pollution has been associated with lung cancer, but the shape of the exposure-response function - especially at low exposure levels - is not well described. The aim of this study was to address the relationship between long-term low-level air pollution exposure and lung cancer incidence.
METHODS
The "Effects of Low-level Air Pollution: a Study in Europe" (ELAPSE) collaboration pools seven cohorts from across Europe. We developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates for nitrogen dioxide (NO
RESULTS
The analyses included 307,550 cohort participants. During a mean follow-up of 18.1 years, 3956 incident lung cancer cases occurred. Median (Q1, Q3) annual (2010) exposure levels of NO
CONCLUSIONS
Long-term ambient PM

Identifiants

DOI: 10.1016/j.envint.2020.106249 PMID: 33197787
pubmed: 33197787
pii: S0160-4120(20)32204-2
doi: 10.1016/j.envint.2020.106249
pii:
doi:

Substances chimiques

Air Pollutants 0
Particulate Matter 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

106249

Subventions

Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Ulla Arthur Hvidtfeldt (UA)

Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address: ullah@cancer.dk.

Gianluca Severi (G)

CESP, UMR 1018, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications "G. Parenti" (DISIA), University of Florence, Italy. Electronic address: gianluca.severi@inserm.fr.

Zorana Jovanovic Andersen (ZJ)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark. Electronic address: zorana.andersen@sund.ku.dk.

Richard Atkinson (R)

Population Health Research Institute and MRC-PHE Centre for Environment and Health, St George's, University of London, London, UK. Electronic address: atkinson@sgul.ac.uk.

Mariska Bauwelinck (M)

Interface Demography - Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: mariska.bauwelinck@vub.ac.be.

Tom Bellander (T)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden. Electronic address: tom.bellander@ki.se.

Marie-Christine Boutron-Ruault (MC)

CESP, UMR 1018, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France. Electronic address: marie-christine.boutron@gustaveroussy.fr.

Jørgen Brandt (J)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark; iClimate - Aarhus University Interdisciplinary Centre for Climate Change, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark. Electronic address: jbr@envs.au.dk.

Bert Brunekreef (B)

Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands.

Giulia Cesaroni (G)

Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, 00147 Rome, Italy. Electronic address: g.cesaroni@deplazio.it.

Jie Chen (J)

Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands. Electronic address: j.chen1@uu.nl.

Hans Concin (H)

Agency for Preventive and Social Medicine, Rheinstraße 61, 6900 Bregenz, Austria. Electronic address: Hans.Concin@aks.or.at.

Francesco Forastiere (F)

Institute for Biomedical Research and Innovation (IRIB), National Research Council, 90146 Palermo, Italy; Environmental Research Group, King's College, London SE1 9NH, UK.

Carla H van Gils (CH)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA Utrecht, the Netherlands. Electronic address: C.vanGils@umcutrecht.nl.

John Gulliver (J)

Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, LE1 7RH, UK. Electronic address: jg435@leicester.ac.uk.

Ole Hertel (O)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark. Electronic address: oh@envs.au.dk.

Gerard Hoek (G)

Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands. Electronic address: G.Hoek@uu.nl.

Barbara Hoffmann (B)

Institute of Occupational, Social and Environmental Medicine, Medical Faculty, Heinrich Heine University, Gurlittstraße 55, 40223 Dusseldorf, Germany. Electronic address: b.hoffmann@uni-duesseldorf.de.

Kees de Hoogh (K)

Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, Postfach, 4001 Basel, Switzerland. Electronic address: c.dehoogh@swisstph.ch.

Nicole Janssen (N)

National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: nicole.janssen@rivm.nl.

Karl-Heinz Jöckel (KH)

Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany. Electronic address: k-h.Joeckel@uk-essen.de.

Jeanette Therming Jørgensen (JT)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark. Electronic address: jethe@sund.ku.dk.

Klea Katsouyanni (K)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece; NIHR HPRU Health Impact of Environmental Hazards, Environmental Research Group, School of Public Health, Imperial College, London, UK. Electronic address: kkatsouy@med.uoa.gr.

Matthias Ketzel (M)

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, United Kingdom. Electronic address: mke@envs.au.dk.

Jochem O Klompmaker (JO)

Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: jochem.klompmaker@rivm.nl.

Norun Hjertager Krog (NH)

Section of Air Pollution and Noise, Norwegian Institute of Public Health, P.O. Box 222, Skøyen, N-0213 Oslo, Norway. Electronic address: NorunHjertager.Krog@fhi.no.

Alois Lang (A)

Cancer Registry Vorarlberg, Agency for Preventive and Social Medicine, Rheinstraße 61, Bregenz 6900, Austria. Electronic address: alois.lang@vol.at.

Karin Leander (K)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address: karin.leander@ki.se.

Shuo Liu (S)

Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark. Electronic address: shli@sund.ku.dk.

Petter L S Ljungman (PLS)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden; Department of Cardiology, Danderyd University Hospital, Stockholm, Sweden. Electronic address: petter.ljungman@ki.se.

Patrik K E Magnusson (PKE)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: patrik.magnusson@ki.se.

Amar Jayant Mehta (AJ)

Statistics Denmark, Sejrøgade 11, 2100 Copenhagen, Denmark; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark. Electronic address: amar.mehta@sund.ku.dk.

Gabriele Nagel (G)

Agency for Preventive and Social Medicine, Rheinstraße 61, 6900 Bregenz, Austria; Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany. Electronic address: gabriele.nagel@uni-ulm.de.

Bente Oftedal (B)

Section of Air Pollution and Noise, Norwegian Institute of Public Health, P.O. Box 222, Skøyen, N-0213 Oslo, Norway. Electronic address: bente.oftedal@fhi.no.

Göran Pershagen (G)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden. Electronic address: goran.pershagen@ki.se.

Raphael Simon Peter (RS)

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany. Electronic address: Raphael.Peter@uni-ulm.de.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Chair of Epidemiology, Ludwig Maximilians Universität München, Munich, Germany. Electronic address: peters@helmholtz-muenchen.de.

Matteo Renzi (M)

Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, 00147 Rome, Italy. Electronic address: m.renzi@deplazio.it.

Debora Rizzuto (D)

Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm 17165, Sweden; Stockholm Gerontology Research Center, Stockholm 11346, Sweden. Electronic address: debora.rizzuto@ki.se.

Sophia Rodopoulou (S)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece. Electronic address: srodopoyl@med.uoa.gr.

Evangelia Samoli (E)

Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece. Electronic address: esamoli@med.uoa.gr.

Per Everhard Schwarze (PE)

Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway. Electronic address: per.schwarze@fhi.no.

Torben Sigsgaard (T)

Department of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Bartholins Allé 2, 8000 Aarhus, Denmark. Electronic address: ts@ph.au.dk.

Mette Kildevæld Simonsen (MK)

Diakonissestiftelsen and Parker Institute, Frederiksberg Hospital, Frederiksberg, Denmark. Electronic address: mksi@ucdiakonissen.dk.

Massimo Stafoggia (M)

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, 00147 Rome, Italy. Electronic address: m.stafoggia@deplazio.it.

Maciek Strak (M)

Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: maciek.strak@rivm.nl.

Danielle Vienneau (D)

Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, Postfach, 4001 Basel, Switzerland. Electronic address: danielle.vienneau@unibas.ch.

Gudrun Weinmayr (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany. Electronic address: Gudrun.Weinmayr@uni-ulm.de.

Kathrin Wolf (K)

Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address: kathrin.wolf@helmholtz-muenchen.de.

Ole Raaschou-Nielsen (O)

Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark. Electronic address: ole@cancer.dk.

Daniela Fecht (D)

UK Small Area Health Statistics Unit, MRC Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK. Electronic address: d.fecht@imperial.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Long-term low-level ambient air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Long-term low-level ambient air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Long-term low-level ambient air pollution...
questionsmedicales.fr › Régions géographiques › Europe › Long-term low-level ambient air pollution...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-term low-level ambient air pollution...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Long-term low-level ambient air pollution...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Long-term low-level ambient air pollution...