Exosomes in Cardiovascular Diseases.
biomarkers
cardiovascular disease
diagnostic
exosomes
extracellular vesicles
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
12 Nov 2020
12 Nov 2020
Historique:
received:
17
10
2020
revised:
08
11
2020
accepted:
10
11
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Exosomes are nano-sized biovesicles of endocytic origin physiologically released by nearly all cell types into surrounding body fluids. They carry cell-specific cargos of protein, lipids, and genetic materials and can be selectively taken up by neighboring or distant cells. Since the intrinsic properties of exosomes are strictly influenced by the state of the parental cell and by the cellular microenvironment, the analysis of exosome origin and content, and their cell-targeting specificity, make them attractive as possible diagnostic and prognostic biomarkers. While the possible role of exosomes as messengers and a regenerative tool in cardiovascular diseases (CVDs) is actively investigated, the evidence about their usefulness as biomarkers is still limited and incomplete. Further complications are due to the lack of consensus regarding the most appropriate approach for exosome isolation and characterization, both important issues for their effective clinical translation. As a consequence, in this review, we will discuss the few information currently accessible about the diagnostic/prognostic potential of exosomes in CVDs and on the methodologies available for exosome isolation, analysis, and characterization.
Identifiants
pubmed: 33198302
pii: diagnostics10110943
doi: 10.3390/diagnostics10110943
pmc: PMC7696149
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : Ricerca Corrente RC 2020 MPP 2B ID 2757640, and 5 × 1000 2018
Références
Cell. 1983 Jul;33(3):967-78
pubmed: 6307529
J Biotechnol. 2013 May 20;165(2):77-84
pubmed: 23562828
Lab Chip. 2013 Aug 7;13(15):2879-82
pubmed: 23743667
Card Fail Rev. 2017 Apr;3(1):7-11
pubmed: 28785469
J Extracell Vesicles. 2013 May 17;2:
pubmed: 24009898
Dev Cell. 2011 Jul 19;21(1):77-91
pubmed: 21763610
J Extracell Vesicles. 2015 Mar 26;4:27269
pubmed: 25819214
Lab Chip. 2012 Dec 21;12(24):5202-10
pubmed: 23111789
PLoS One. 2012;7(3):e30679
pubmed: 22427800
Methods. 2015 Oct 1;87:64-74
pubmed: 25843788
Nat Cell Biol. 2010 Jan;12(1):19-30; sup pp 1-13
pubmed: 19966785
Anal Chem. 2011 May 1;83(9):3499-506
pubmed: 21434639
Nat Protoc. 2016 Apr;11(4):664-87
pubmed: 26963630
J Extracell Vesicles. 2017 Jul 12;6(1):1350088
pubmed: 28804599
Sci Rep. 2017 Dec 12;7(1):17479
pubmed: 29234015
Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652):
pubmed: 25135963
Mol Pharm. 2019 Aug 5;16(8):3333-3349
pubmed: 31241965
Annu Rev Physiol. 2015;77:13-27
pubmed: 25293529
J Extracell Vesicles. 2013 Feb 15;2:
pubmed: 24009893
Circ Res. 2010 Sep 3;107(5):677-84
pubmed: 20595655
J Cardiothorac Vasc Anesth. 2021 Mar;35(3):780-785
pubmed: 32571657
Kaohsiung J Med Sci. 2018 Nov;34(11):626-633
pubmed: 30392569
Front Pharmacol. 2020 Jan 20;10:1500
pubmed: 32038230
Theranostics. 2019 Sep 21;9(23):6901-6919
pubmed: 31660076
Transl Psychiatry. 2019 Mar 28;9(1):122
pubmed: 30923321
Sci Rep. 2017 Dec;7(1):47
pubmed: 28246388
Eur J Pharm Biopharm. 2016 Jan;98:1-8
pubmed: 26545617
Methods Mol Biol. 2017;1660:221-232
pubmed: 28828660
Front Physiol. 2018 Oct 23;9:1479
pubmed: 30405435
JCI Insight. 2016 Nov 17;1(19):e89631
pubmed: 27882350
Stem Cell Res. 2010 May;4(3):214-22
pubmed: 20138817
Nanotechnology. 2018 Apr 3;29(13):132001
pubmed: 29376505
Circ Res. 2015 Jan 16;116(2):255-63
pubmed: 25344555
J Extracell Vesicles. 2015 Mar 31;4:25530
pubmed: 25833224
Front Immunol. 2020 Sep 10;11:2175
pubmed: 33013913
Diabetes. 2002 Jun;51(6):1949-56
pubmed: 12031985
J Extracell Vesicles. 2014 Sep 08;3:
pubmed: 25279113
PLoS One. 2016 Apr 29;11(4):e0154274
pubmed: 27128471
Biomed Res Int. 2020 Jun 10;2020:5424281
pubmed: 32596327
Front Endocrinol (Lausanne). 2014 Sep 26;5:149
pubmed: 25309511
Crit Care. 2018 Mar 15;22(1):68
pubmed: 29540208
J Cell Physiol. 2019 Aug;234(8):12422-12432
pubmed: 30637729
J Extracell Vesicles. 2015 Dec 07;4:28533
pubmed: 26649679
Langmuir. 2015 Jun 16;31(23):6577-87
pubmed: 25970769
Eur Heart J. 2010 Mar;31(6):659-66
pubmed: 20159880
Int J Mol Sci. 2019 Sep 06;20(18):
pubmed: 31489895
J Thromb Haemost. 2010 Feb;8(2):315-23
pubmed: 19840362
Oncotarget. 2017 Apr 18;8(33):55632-55645
pubmed: 28903450
Trends Cancer. 2020 Sep;6(9):767-774
pubmed: 32307267
J Am Coll Cardiol. 2015 Apr 21;65(15):1525-36
pubmed: 25881934
Circ Res. 2013 Jul 19;113(3):322-6
pubmed: 23743335
Curr Opin Cell Biol. 2014 Aug;29:116-25
pubmed: 24959705
Trends Cell Biol. 2014 Jan;24(1):19-25
pubmed: 24287454
Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22
pubmed: 18228490
J Extracell Vesicles. 2018 Aug 20;7(1):1508271
pubmed: 30151077
Cell Death Dis. 2018 Feb 23;9(3):320
pubmed: 29476052
Nat Cell Biol. 2012 Feb 12;14(3):249-56
pubmed: 22327366
J Mol Cell Cardiol. 2012 Dec;53(6):848-57
pubmed: 23085511
Front Neurol. 2017 Feb 27;8:57
pubmed: 28289400
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Int J Mol Med. 2017 Sep;40(3):834-844
pubmed: 28737826
Eur Heart J. 2019 Mar 21;40(12):953-956
pubmed: 30896768
PLoS One. 2017 Sep 25;12(9):e0185406
pubmed: 28945793
Genes Cancer. 2013 Jul;4(7-8):261-72
pubmed: 24167654
J Mol Cell Cardiol. 2014 Mar;68:75-8
pubmed: 24440457
Science. 2004 May 14;304(5673):987-90
pubmed: 15143275
J Extracell Vesicles. 2018 Feb 15;7(1):1435138
pubmed: 29511460
Mol Ther Nucleic Acids. 2017 Sep 15;8:494-507
pubmed: 28918050
Nat Commun. 2019 Feb 27;10(1):959
pubmed: 30814518
Neural Plast. 2017;2017:7027380
pubmed: 28770113
World J Stem Cells. 2018 Aug 26;10(8):106-115
pubmed: 30190780
Am J Transl Res. 2018 Dec 15;10(12):4350-4366
pubmed: 30662677
Ann Clin Transl Neurol. 2017 Nov 24;5(1):4-10
pubmed: 29376087
Heliyon. 2019 Oct 21;5(10):e02633
pubmed: 31687497
Int J Mol Sci. 2016 Jan 05;17(1):
pubmed: 26742038
PLoS One. 2014 Feb 18;9(2):e88685
pubmed: 24558412
Circ Cardiovasc Genet. 2011 Aug 1;4(4):446-54
pubmed: 21642241
Sci Rep. 2017 Sep 12;7(1):11271
pubmed: 28900146
Sci Rep. 2018 Jul 9;8(1):10306
pubmed: 29985466
Int J Clin Exp Pathol. 2017 Aug 01;10(8):8383-8388
pubmed: 31966690
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Cell Mol Life Sci. 2018 Jan;75(2):193-208
pubmed: 28733901
Nitric Oxide. 2019 Aug 1;89:32-40
pubmed: 31051258
Adv Healthc Mater. 2019 Mar;8(6):e1801268
pubmed: 30663276
Int J Cardiol. 2015 Jan 15;178:239-46
pubmed: 25464262
Nanomicro Lett. 2019 Sep 17;11(1):77
pubmed: 34138050
Biomed Pharmacother. 2020 Jan;121:109593
pubmed: 31766102
Front Oncol. 2019 Jul 16;9:651
pubmed: 31380286
J Cell Physiol. 2007 Jul;212(1):174-81
pubmed: 17299798
PLoS One. 2015 Sep 22;10(9):e0138849
pubmed: 26393803
Nanomedicine. 2011 Dec;7(6):780-8
pubmed: 21601655
Circ Res. 2015 Jun 19;117(1):52-64
pubmed: 25904597
PLoS One. 2011;6(12):e28324
pubmed: 22163007
PLoS One. 2016 Sep 23;11(9):e0163645
pubmed: 27661079
Biochim Biophys Acta. 2015 Nov;1852(11):2362-71
pubmed: 26300484
Mol Med Rep. 2019 Apr;19(4):3298-3304
pubmed: 30816508
Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):146-50
pubmed: 21640565
J Thromb Haemost. 2014 Nov;12(11):1906-17
pubmed: 25163645
Proteomics Clin Appl. 2015 Apr;9(3-4):358-67
pubmed: 25684126
J Thromb Haemost. 2011 Jun;9(6):1216-24
pubmed: 21481178
Biochem Biophys Res Commun. 1983 Jun 15;113(2):650-8
pubmed: 6870878
Theranostics. 2018 Feb 14;8(7):1869-1878
pubmed: 29556361
EMBO J. 2015 Oct 1;34(19):2398-407
pubmed: 26311197
J Cell Mol Med. 2010 May;14(5):1064-70
pubmed: 20465578
Circ Res. 2014 Jan 17;114(2):315-24
pubmed: 24436427
Lab Chip. 2017 Oct 25;17(21):3558-3577
pubmed: 28832692
J Biol Chem. 2013 Apr 26;288(17):11649-61
pubmed: 23463506
Annu Rev Physiol. 2016;78:67-83
pubmed: 26667071
Stem Cell Res. 2013 May;10(3):301-12
pubmed: 23399448
Diagnostics (Basel). 2020 Oct 19;10(10):
pubmed: 33086718
Int J Mol Sci. 2019 Jun 11;20(11):
pubmed: 31212641
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Biochem Biophys Res Commun. 2013 Feb 15;431(3):566-71
pubmed: 23318173
Mol Immunol. 2017 Jul;87:114-121
pubmed: 28433888
Lab Chip. 2010 Feb 21;10(4):505-11
pubmed: 20126692
Adv Exp Med Biol. 2017;998:101-112
pubmed: 28936735
Biol Chem. 2020 Feb 25;401(3):367-376
pubmed: 31318684
Cytometry A. 2014 Sep;85(9):756-70
pubmed: 24903900
Onco Targets Ther. 2020 Oct 23;13:10765-10774
pubmed: 33122915
J Mol Cell Cardiol. 2014 Sep;74:139-50
pubmed: 24825548
Semin Cancer Biol. 2014 Oct;28:3-13
pubmed: 24769058
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3052-6
pubmed: 17307989
Phys Rev Lett. 1986 Mar 3;56(9):930-933
pubmed: 10033323
Cold Spring Harb Protoc. 2015 Apr 01;2015(4):319-23
pubmed: 25834266
Methods Mol Biol. 2018;1740:69-83
pubmed: 29388137
Stem Cell Res Ther. 2018 Jul 4;9(1):180
pubmed: 29973270
ScientificWorldJournal. 2015;2015:657086
pubmed: 25695100
Eur J Heart Fail. 2012 Feb;14(2):147-54
pubmed: 22120965
J Am Heart Assoc. 2016 Oct 17;5(10):
pubmed: 27792649
J Extracell Vesicles. 2013 May 27;2:
pubmed: 24009894
Adv Exp Med Biol. 2017;998:113-138
pubmed: 28936736
Semin Cell Dev Biol. 2018 Feb;74:66-77
pubmed: 28807885
Kidney Int. 2012 Nov;82(9):1024-32
pubmed: 22785172
J Extracell Vesicles. 2015 Jul 17;4:27031
pubmed: 26194179
Sci Rep. 2016 Apr 18;6:24316
pubmed: 27087061
Theranostics. 2017 Jan 26;7(3):789-804
pubmed: 28255367
Eur Heart J. 2017 Jan 14;38(3):201-211
pubmed: 28158410
Methods Mol Biol. 2011;728:235-46
pubmed: 21468952
Nanomedicine. 2015 May;11(4):879-83
pubmed: 25659648
J Neurovirol. 2019 Oct;25(5):702-709
pubmed: 30610738
Cells. 2019 Feb 17;8(2):
pubmed: 30781555
Int J Clin Exp Med. 2015 Mar 15;8(3):4275-80
pubmed: 26064341
Nat Protoc. 2012 Jun 14;7(7):1311-26
pubmed: 22722367
Int J Mol Sci. 2016 Feb 06;17(2):173
pubmed: 26861304
Exp Ther Med. 2019 Jul;18(1):179-187
pubmed: 31258652
Lab Chip. 2014 Jun 7;14(11):1891-900
pubmed: 24722878
Traffic. 2009 Jul;10(7):925-37
pubmed: 19490536
J Cell Mol Med. 2016 Dec;20(12):2318-2327
pubmed: 27515767