First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary via the mTOR pathway.
Autophagy
Cadmium toxicity
Endocrine disruptor
Melatonin
Oxidative stress
mTOR pathway
Journal
Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
28
06
2020
revised:
11
09
2020
accepted:
06
11
2020
pubmed:
18
11
2020
medline:
22
1
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
Herein, the first evidence of the ability of melatonin (MLT) to counteract cadmium (Cd) toxic effects on the rat ovary is reported. Cd treatment, enhancing oxidative stress, provoked clear morphological, histological and biomolecular alterations, i.e. in the estrous cycle duration, in the ovarian and serum E
Identifiants
pubmed: 33199064
pii: S0269-7491(20)36745-2
doi: 10.1016/j.envpol.2020.116056
pii:
doi:
Substances chimiques
Cadmium
00BH33GNGH
mTOR protein, rat
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116056Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.