Association Between Human Papillomavirus Infection and Outcome of Perioperative Nodal Radiotherapy for Penile Carcinoma.
Adjuvant radiotherapy
Comprehensive genomic profiling
Human papillomavirus infection
Penile cancer
Squamous-cell carcinoma
Journal
European urology oncology
ISSN: 2588-9311
Titre abrégé: Eur Urol Oncol
Pays: Netherlands
ID NLM: 101724904
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
07
08
2020
revised:
20
10
2020
accepted:
30
10
2020
pubmed:
18
11
2020
medline:
2
2
2022
entrez:
17
11
2020
Statut:
ppublish
Résumé
Data on the impact of human papillomavirus (HPV) infection status and outcomes for perioperative treatments for patients with lymph node-involved penile squamous-cell carcinoma (PSCC) are lacking. To analyze the benefit from perioperative radiotherapy (RT) for PSCC according to HPV infection status. In an international multicenter database of 1254 patients with PSCC who received inguinal lymph node dissection (ILND), 507 had suitable clinical information. ILND, with or without chemotherapy or RT for involved lymph nodes. Kaplan-Meier and restricted mean survival time (RMST) analyses for overall survival (OS) were performed for all patients and after propensity score-matching (PSM; n = 136), for which patient age, histology, type of penile surgical procedure, pathological tumor and nodal stage, ILND laterality, pelvic LND, and perioperative treatment were taken into account when assessing differences between HPV Patients with HPV Perioperative RT was more effective in the HPV We analyzed data from a large multicenter database for patients with penile cancer who had received inguinal lymph node dissection, with or without chemotherapy or radiotherapy. We found that for tumors positive for human papillomavirus (HPV), use of radiotherapy resulted in prolonged survival compared to HPV-negative tumors. On the basis of these results we are inspired to design studies on the use of radiotherapy in HPV-selected patients.
Sections du résumé
BACKGROUND
Data on the impact of human papillomavirus (HPV) infection status and outcomes for perioperative treatments for patients with lymph node-involved penile squamous-cell carcinoma (PSCC) are lacking.
OBJECTIVE
To analyze the benefit from perioperative radiotherapy (RT) for PSCC according to HPV infection status.
DESIGN, SETTING, AND PARTICIPANTS
In an international multicenter database of 1254 patients with PSCC who received inguinal lymph node dissection (ILND), 507 had suitable clinical information.
INTERVENTION
ILND, with or without chemotherapy or RT for involved lymph nodes.
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS
Kaplan-Meier and restricted mean survival time (RMST) analyses for overall survival (OS) were performed for all patients and after propensity score-matching (PSM; n = 136), for which patient age, histology, type of penile surgical procedure, pathological tumor and nodal stage, ILND laterality, pelvic LND, and perioperative treatment were taken into account when assessing differences between HPV
RESULTS AND LIMITATIONS
Patients with HPV
CONCLUSIONS
Perioperative RT was more effective in the HPV
PATIENT SUMMARY
We analyzed data from a large multicenter database for patients with penile cancer who had received inguinal lymph node dissection, with or without chemotherapy or radiotherapy. We found that for tumors positive for human papillomavirus (HPV), use of radiotherapy resulted in prolonged survival compared to HPV-negative tumors. On the basis of these results we are inspired to design studies on the use of radiotherapy in HPV-selected patients.
Identifiants
pubmed: 33199252
pii: S2588-9311(20)30176-0
doi: 10.1016/j.euo.2020.10.011
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
802-810Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.