Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 11 2020
16 11 2020
Historique:
received:
09
06
2020
accepted:
05
11
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
12
3
2021
Statut:
epublish
Résumé
Cancer is one of the main causes of mortality in the world. Many cancer cells produce ATP through high-level lactic acid fermentation catalyzed by lactate dehydrogenase (LDH), which converts pyruvic acid to lactic acid. LDH plays a dominant role in the Warburg effect, wherein aerobic glycolysis is favored over oxidative phosphorylation. Due to the high lactic acid production level in cancer cells, LDH-targeting could be a potential cancer treatment strategy. A few approaches, such as drug treatment, reportedly inhibited LDH activity. In this study, we describe new 1,3-benzodioxole derivatives that might be potential small molecule candidates for LDHA inhibition. The synthesis was carried out by trans-esterification between aryl ester and alcohol groups from piperonyl alcohol. Compounds 2 and 10 exhibited a selective LDHA IC
Identifiants
pubmed: 33199724
doi: 10.1038/s41598-020-77056-4
pii: 10.1038/s41598-020-77056-4
pmc: PMC7669867
doi:
Substances chimiques
Antineoplastic Agents
0
Dioxoles
0
Enzyme Inhibitors
0
L-Lactate Dehydrogenase
EC 1.1.1.27
1,3-benzodioxole
F0XLL582B8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19889Références
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