The conformational cycle of a prototypical voltage-gated sodium channel.
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
03
2020
accepted:
07
08
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
22
1
2021
Statut:
ppublish
Résumé
Electrical signaling was a dramatic development in evolution, allowing complex single-cell organisms like Paramecium to coordinate movement and early metazoans like worms and jellyfish to send regulatory signals rapidly over increasing distances. But how are electrical signals generated in biology? In fact, voltage-gated sodium channels conduct sodium currents that initiate electrical signals in all kingdoms of life, from bacteria to man. They are responsible for generating the action potential in vertebrate nerve and muscle, neuroendocrine cells, and other cell types
Identifiants
pubmed: 33199904
doi: 10.1038/s41589-020-0644-4
pii: 10.1038/s41589-020-0644-4
pmc: PMC7678813
mid: NIHMS1616158
doi:
Substances chimiques
NAV1.5 Voltage-Gated Sodium Channel
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1314-1320Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL112808
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS015751
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS111573
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Références
Hodgkin, A. L. & Huxley, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500–544 (1952).
doi: 10.1113/jphysiol.1952.sp004764
pubmed: 12991237
Hille, B. Ion Channels of Excitable Membranes, 3rd Ed (Sinauer Associates Inc., 2001).
Catterall, W. A. The molecular basis of neuronal excitability. Science 223, 653–661 (1984).
doi: 10.1126/science.6320365
pubmed: 6320365
Numa, S. & Noda, M. Molecular structure of sodium channels. Ann. NY Acad. Sci. 479, 338–355 (1986).
doi: 10.1111/j.1749-6632.1986.tb15580.x
pubmed: 2434000
Catterall, W. A., Wisedchaisri, G. & Zheng, N. The chemical basis for electrical signaling. Nat. Chem. Biol. 13, 455–463 (2017).
doi: 10.1038/nchembio.2353
pubmed: 28406893
pmcid: 5464002
Ren, D. et al. A prokaryotic voltage-gated sodium channel. Science 294, 2372–2375 (2001).
doi: 10.1126/science.1065635
pubmed: 11743207
Payandeh, J., Scheuer, T., Zheng, N. & Catterall, W. A. The crystal structure of a voltage-gated sodium channel. Nature 475, 353–358 (2011).
doi: 10.1038/nature10238
pubmed: 21743477
pmcid: 3266868
Payandeh, J., Gamal El-Din, T. M., Scheuer, T., Zheng, N. & Catterall, W. A. Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature 486, 135–139 (2012).
doi: 10.1038/nature11077
pubmed: 22678296
pmcid: 3552482
Lenaeus, M. J. et al. Structures of closed and open states of a voltage-gated sodium channel. Proc. Natl Acad. Sci. USA 114, E3051–E3060 (2017).
doi: 10.1073/pnas.1700761114
pubmed: 28348242
pmcid: 5393245
Wisedchaisri, G. et al. Resting-state structure and gating mechanism of a voltage-gated sodium channel. Cell 178, 993–1003.e12 (2019).
doi: 10.1016/j.cell.2019.06.031
pubmed: 31353218
pmcid: 6688928
McCusker, E. C. et al. Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat. Commun. 3, 1102 (2012).
doi: 10.1038/ncomms2077
pubmed: 23033078
Catterall, W. A. Molecular properties of voltage-sensitive sodium channels. Annu. Rev. Biochem. 55, 953–985 (1986).
doi: 10.1146/annurev.bi.55.070186.004513
pubmed: 2427018
Yarov-Yarovoy, V. et al. Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc. Natl Acad. Sci. USA 109, E93–E102 (2012).
doi: 10.1073/pnas.1118434109
pubmed: 22160714
Tao, X., Lee, A., Limapichat, W., Dougherty, D. A. & MacKinnon, R. A gating charge transfer center in voltage sensors. Science 328, 67–73 (2010).
doi: 10.1126/science.1185954
pubmed: 20360102
pmcid: 2869078
Chakrabarti, N. et al. Catalysis of Na
doi: 10.1073/pnas.1309452110
pubmed: 23803856
pmcid: 3710854
Pavlov, E. et al. The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel. Biophys. J. 89, 232–242 (2005).
doi: 10.1529/biophysj.104.056994
pubmed: 15849254
pmcid: 1366521
Gamal El-Din, T. M., Lenaeus, M. J., Ramanadane, K., Zheng, N. & Catterall, W. A. Molecular dissection of multiphase inactivation of the bacterial sodium channel Na
doi: 10.1085/jgp.201711884
pubmed: 30510035
pmcid: 6363407
Jiang, D. et al. Structure of the cardiac sodium channel. Cell 180, 122–134.e10 (2020).
doi: 10.1016/j.cell.2019.11.041
pubmed: 31866066
Chanda, B. & Bezanilla, F. Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. J. Gen. Physiol. 120, 629–645 (2002).
doi: 10.1085/jgp.20028679
pubmed: 12407076
pmcid: 2229551
Lacroix, J. J., Campos, F. V., Frezza, L. & Bezanilla, F. Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation. Neuron 79, 651–657 (2013).
doi: 10.1016/j.neuron.2013.05.036
pubmed: 23972594
pmcid: 3907179
Pan, X. et al. Structure of the human voltage-gated sodium channel Na
doi: 10.1126/science.aau2486
pubmed: 30190309
Shen, H., Liu, D., Wu, K., Lei, J. & Yan, N. Structures of human Na
doi: 10.1126/science.aaw2493
pubmed: 30765606
Capes, D. L., Goldschen-Ohm, M. P., Arcisio-Miranda, M., Bezanilla, F. & Chanda, B. Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels. J. Gen. Physiol. 142, 101–112 (2013).
doi: 10.1085/jgp.201310998
pubmed: 23858005
pmcid: 3727307
Gamal El-Din, T. M., Lenaeus, M. J., Zheng, N. & Catterall, W. A. Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl Acad. Sci. USA 115, 13111–13116 (2018).
doi: 10.1073/pnas.1814928115
pubmed: 30518562
pmcid: 6304959
Boiteux, C. et al. Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proc. Natl Acad. Sci. USA 111, 13057–13062 (2014).
doi: 10.1073/pnas.1408710111
pubmed: 25136136
pmcid: 4246943
Nguyen, P. T., DeMarco, K. R., Vorobyov, I., Clancy, C. E. & Yarov-Yarovoy, V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc. Natl Acad. Sci. USA 116, 2945–2954 (2019).
doi: 10.1073/pnas.1817446116
pubmed: 30728299
pmcid: 6386684
Wu, J. et al. Structure of the voltage-gated calcium channel Ca
doi: 10.1038/nature19321
pubmed: 27580036
Tang, L. et al. Structural basis for Ca
doi: 10.1038/nature12775
pubmed: 24270805
Yu, F. H. & Catterall, W. A. The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci. STKE 2004, re15 (2004).
doi: 10.1126/stke.2532004re15
pubmed: 15467096
Long, S. B., Tao, X., Campbell, E. B. & MacKinnon, R. Atomic structure of a voltage-dependent K
doi: 10.1038/nature06265
pubmed: 18004376
Jorgensen, C. et al. Lateral fenestrations in K
doi: 10.1021/acs.molpharmaceut.5b00942
pubmed: 27173896
Pan, X. et al. Molecular basis for pore blockade of human Na
doi: 10.1126/science.aaw2999
pubmed: 30765605